The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Revi
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REVIEW ARTICLE
The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials Reza Tabrizi1 • Maryam Akbari1 • Nasrin Sharifi2 • Kamran B. Lankarani3 Mahmood Moosazadeh4 • Fariba Kolahdooz5 • Mohsen Taghizadeh2 • Zatollah Asemi2
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Received: 21 November 2017 / Accepted: 30 December 2017 Ó Springer International Publishing AG, part of Springer Nature 2018
Abstract Introduction Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial. Aim This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases. Methods Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI).
Results A total of seventeen randomized controlled trials (684 participants) were included. Results showed that CoQ10 supplementation significantly decreased systolic blood pressure (SBP) (SMD - 0.30; 95% CI - 0.52, - 0.08). However, CoQ10 supplementation decreased diastolic blood pressure (DBP), but this was not statistically significant (SMD - 0.08; 95% CI - 0.46, 0.29). Conclusions CoQ10 supplementation may result in reduction in SBP levels, but did not affect DBP levels among patients with metabolic diseases. Additional prospective studies regarding the effect of CoQ10 supplementation on blood pressure in patients with metabolic diseases are necessary.
& Zatollah Asemi [email protected]
Hypertension is a main risk factor for diseases related to metabolic disorders, including diabetes, dyslipidemia, myocardial infarction, heart failure, stroke, peripheral arterial disease, and chronic kidney disease [1]. Major risk factors of hypertension include, but are not limited to, smoking, sedentary lifestyle, a diet high in sodium, and an inadequate intake of few minerals, including potassium, calcium and magnesium [2]. Hypertension is currently managed by the consumption of a variety of drugs. Blood pressure-lowering agents are effective in reducing blood pressure, but many have undesirable side effects, including renal or cardiac dysfunction, cough and depression [3]. Coenzyme Q10 (CoQ10), also known as ubiquinone due to its ubiquitous distribution in nature, is a vitamin like antioxidant and an integral component of the mitochondrial
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Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Scienc
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