Colorectal resection via natural orifice specimen extraction versus conventional laparoscopic extraction: a meta-analysi
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Colorectal resection via natural orifice specimen extraction versus conventional laparoscopic extraction: a meta‑analysis with meta‑regression Y. H. Chin1 · G. M. Decruz1 · C. H. Ng1 · H. Q. M. Tan1 · F. Lim1,2 · F. J. Foo3 · C. H. Tai2 · C. S. Chong1,2 Received: 3 May 2020 / Accepted: 13 August 2020 © Springer Nature Switzerland AG 2020
Abstract Background Studies have shown differences in postoperative outcomes between two minimally invasive extraction methods for colorectal lesions—natural orifice specimen extraction surgery (NOSES) and conventional laparoscopic surgery (CLS). The aim of this study was to discover the major differences in NOSES and CLS to refine current practice. Methods Electronic databases were searched for articles comparing NOSES and CLS from inception till March 2020. Weighted mean differences (WMD) and odds ratio (OR) were estimated for continuous and dichotomous outcomes, respectively. Summary statistics were calculated using the DerSimonian and Laird random effects. Results Twenty-one studies (15 on malignant disease, 4 on benign disease, 2 on both) were included in this meta-analysis, totalling 2378 patients (1079 NOSE, 1299 CLS). NOSE was associated with decreased: intraoperative bleeding (WMD: − 10.652 ml; 95% CI: − 18.818 ml to − 2.482 ml; p
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