Comparison Between CBCT and Fusion PET/CT-CBCT Guidance for Lung Biopsies
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CLINICAL INVESTIGATION
INTERVENTIONAL ONCOLOGY
Comparison Between CBCT and Fusion PET/CT-CBCT Guidance for Lung Biopsies Federico Fontana1,2 • Filippo Piacentino1 • Anna Maria Ierardi3,4 • Gianpaolo Carrafiello3,4 • Andrea Coppola1 • Alessandra Muollo5 • Alessandro Beneventi6 • Chiara Floridi7 • Andrea Selenito Imperatori2,8 Giulio Carcano2,9 • Massimo Venturini1,2
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Received: 30 March 2020 / Accepted: 2 August 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2020
Abstract Purpose To establish the feasibility of performing percutaneous biopsy of lung lesions guided by fusion PET/CTCBCT and to evaluate whether the metabolic information provided by a prior PET/CT scan add incremental benefits for diagnosis. Methods We retrospectively reviewed data from 180 patients who underwent CBCT-guided lung biopsy (group 1—90 cases) or PET/CT-CBCT fusion-guided lung biopsy (group 2—90 cases). Technical and clinical success was calculated. We also evaluated the agreement between biopsy and definitive histology and the possibility to carrying out immunehistochemical and molecular biology analyses. & Andrea Coppola [email protected] 1
Diagnostic and Interventional Radiology Department, Ospedale di Circolo e Fondazione Macchi, ASST dei Sette Laghi, Via Guicciardini, 9, 21100 Varese, Italy
Results Technical success was achieved in 84/90 (93.3%) cases for group 1 and 89/90 (98.9%) for group 2 cases (p 0.054). Clinical success was achieved in 80/94 (95.2%) cases for group 1 and 88/89 (98.9%) cases for group 2. Sensitivity, specificity, positive and negative predictive values and accuracy rate were, respectively, 94.5%, 100.0%, 100.0%, 73.3% and 95.2% for group 1 and 98.6%, 100.0%, 100.0%, 94.4% and 98.9% for group 2 (p 0.167). Agreement between biopsy and definitive histology was reached in 85.7% for group 1 and in 96.2% for group 2 (p 0.211). Immunohistochemical and molecular biology investigations were possible in 66.7% for group 1 and in 77.0% for group 2 (p 0.297). No major complication occurred. Conclusions PET/CT-CBCT-guided lung biopsy is a feasible technique. In our retrospective case series, we found a higher clinical success rate, but no statistical difference was found. Keywords Fusion imaging Lung biopsy CBCT Interventional radiology Oncology
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Universita` degli Studi dell’Insubria, Varese, Italy
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Diagnostic and Interventional Radiology Department, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan, Italy
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Universita` degli Studi di Milano, Milan, Italy
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Radiology Department, Ospedale di Legnano, ASST Ovest Milanese, Legnano, MI, Italy
Introduction
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Diagnostic and Interventional Radiology Department, Ospedale Sant’Anna, ASST Lariana, Como, Italy
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Universita` Politecnica delle Marche, Ancona, Italy
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Thoracic Surgery Department, Ospedale di Circolo e Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy
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Surgery Department, Ospedale di Circolo e Fondazione Macchi, ASST dei Set
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