Computational Methods in Systems Biology 6th International Conferenc
This book constitutes the refereed proceedings of the 6th International Conference on Computational Methods in Systems Biology, CMSB 2008, held in Rostock, Germany, in September 2008. The 21 revised full papers presented together with the summaries of 5 i
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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong
Subseries of Lecture Notes in Computer Science
Monika Heiner Adelinde M. Uhrmacher (Eds.)
Computational Methods in Systems Biology 6th International Conference, CMSB 2008 Rostock, Germany, October 12-15, 2008 Proceedings
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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Monika Heiner Institute of Computer Science Brandenburg University of Technology Cottbus, Germany E-mail: [email protected] Adelinde M. Uhrmacher Institute of Computer Science University of Rostock Rostock, Germany E-mail: [email protected]
Library of Congress Control Number: Applied for
CR Subject Classification (1998): I.6, D.2.4, J.3, H.2.8, F.1.1 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13
0302-9743 3-540-88561-7 Springer Berlin Heidelberg New York 978-3-540-88561-0 Springer Berlin Heidelberg New York
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2008 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12537532 06/3180 543210
Preface
This volume contains the proceedings of the 6th Conference on Computational Methods in Systems Biology (CMSB) held in October 2008 in Rostock/ Warnem¨ unde. The CMSB conference series was established in 2003 to promote the convergence of (1) modelers, physicists, mathematicians, and theoretical computer scientists from fields such as language design, concurrency theory, software verification, and (2) molecular biologists, physicians, neuroscientists joined by their interest in a systems-level understanding of cellular physiology and pathology. Since this time, the conference has taken place annually. The conference has been held in Italy, France, and the UK, and we were glad to host CMSB in Germany for the first time. The summaries of the invited talks by Hidde de Jong, Jane Hillston, Koichi Takahashi, Nicolas Le Novere, and Dieter Oesterhelt are included at the beginning of the proceedings. The 21 regular papers cover theoretical or applied contributions that a
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