Computational Protein Design
The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein
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Ilan Samish Editor
Computational Protein Design
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Computational Protein Design Edited by
Ilan Samish Department of Plants and Environmental Sciences Weizmann Institute of Science, Rehovot, Israel Department of Biotechnology Engineering Braude Academic College of Engineering, Karmiel, Israel Amai Proteins Ltd., Ashdod, Israel
Editor Ilan Samish Department of Plants and Environmental Sciences Weizmann Institute of Science, Rehovot, Israel Department of Biotechnology Engineering Braude Academic College of Engineering, Karmiel, Israel Amai Proteins Ltd., Ashdod, Israel
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6635-6 ISBN 978-1-4939-6637-0 (eBook) DOI 10.1007/978-1-4939-6637-0 Library of Congress Control Number: 2016959982 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The aim of this first-ever book entitled Computational Protein Design (CPD) is to bring the latest know-how on the CPD methods in respect to the process, success, and pitfalls of the field. The book is organized so as to introduce and present the general methodology and main challenges followed by a description of specific software and applications. As seen in the description below, there is more than one way to cluster the different chapters, each highlighting a different aspect of the field. While there has not been a book dedicated to CPD, books on protein design have often included chapters on CPD. Here, following a chapter on the framework of CPD (Chapter 1)
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