Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer
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RESEARCH
Open Access
Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer Naoya Ishibashi1*, Toshiya Maebayashi1, Takuya Aizawa1, Masakuni Sakaguchi1, Haruna Nishimaki2 and Shinobu Masuda2
Abstract Background: In the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could predict the therapeutic response to radiation therapy in small cell lung cancer (SCLC). Methods: Data from 19 SCLC patients who received thoracic radiation therapy were included. Clinical staging was assessed using the TNM classification system (UICC, 2009; cstage IIA/IIB/IIIA/IIIB = 3/1/7/8). Ki-67 was detected using immunostained tumour sections and the Ki-67 proliferation index was determined using e-Count software. Radiation therapy was administered at total doses of 45–60 Gy. A total of 16 of the 19 patients received chemotherapy. Results: Patients were divided into two groups, one with a Ki-67 proliferation index ≥79.77% (group 1, 8 cases) and the other with a Ki-67 proliferation index
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