Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma
- PDF / 615,243 Bytes
- 11 Pages / 595.28 x 793.7 pts Page_size
- 1 Downloads / 185 Views
WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma Gang Zhao1,2, Zi-ming Huang3, Ya-Lin Kong1, Dong-Qing Wen4, Yu Li2, Li Ren5 and Hong-Yi Zhang1*
Abstract Background: Cortactin is an important regulator involved in invasion and migration of hepatocellular carcinoma (HCC). The aim of this study was to elucidate the forecasting role of cortactin in resectable HCCs. Methods: We compared the invasiveness and motility among liver epithelial cell line and HCC cell lines by using Transwell assay and wound healing assay. We further investigated the CTTN mRNA expression by real-time PCR. Next, 91 HCC and 20 normal liver tissue samples were detected by IHC and real-time PCR. Finally, we analyzed the clinicopathologic features and survival time of the HCC cases. Results: We identified that HepG2, LM3, and SK-Hep-1 had more invasiveness and motility (P
Data Loading...
