Corticosteroids could improve the renal outcome of IgA nephropathy with moderate proteinuria
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NEPHROLOGY - ORIGINAL PAPER
Corticosteroids could improve the renal outcome of IgA nephropathy with moderate proteinuria ZhengXia Zhong1,2 · Yi Tang1 · JiaXing Tan1,3 · Li Tan1,3 · GaiQin Pei1,3 · Wei Qin1 Received: 15 June 2020 / Accepted: 7 September 2020 © Springer Nature B.V. 2020
Abstract Background The specific treatment regimens of IgA nephropathy (IgAN) patients with moderate proteinuria (1.0–3.5 g/ day) remain controversial. The purpose of this study was to explore the optimized therapeutic regimen for IgAN patients through analyzing the clinical data. Methods A retrospective study was conducted, 449 patients with biopsy-proven IgAN were enrolled. Patients were divided into three groups according to proteinuria levels: urine protein 1.0–1.5 g/day (UP1, n = 111), urine protein 1.5–2.5 g/day (UP2, n = 213), urine protein 2.5–3.5 g/day (UP3, n = 125). Clinical pathological features, treatment regimens and renal outcome were compared. Responses to therapy included complete remission (CR), partial remission (PR), no response (NR) and end-stage renal disease (ESRD). The composite endpoints of renal outcome were defined as 50% decline in eGFR and/ or progressing into end-stage renal disease. Results During the average follow-up of 44.27 months, 71 (63.9%), 150 (70.4%) and 68 (54.4%) patients achieved CR + PR among three groups, respectively. Whereas 15 (13.5%), 28 (13.1%) and 39 (31.2%) patients progressed to the primary endpoint (P
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