Cough: Pathophysiology, Diagnosis and Treatment

This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understandin

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Cough: Pathophysiology, Diagnosis and Treatment

Alessandro Zanasi Giovanni A. Fontana  •  Donatella Mutolo Editors

Cough: Pathophysiology, Diagnosis and Treatment

Editors Alessandro Zanasi Cough Study and Treatment Centre S.I.S.Me.R. Bologna Italy Donatella Mutolo Department of Experimental and Clinical Medicine - Section of Physiology University of Florence Florence Italy

Giovanni A. Fontana Department of Critical Care Medicine and Surgery University of Florence Florence Italy

ISBN 978-3-030-48570-2    ISBN 978-3-030-48571-9 (eBook) https://doi.org/10.1007/978-3-030-48571-9 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

To John G. Widdicombe (1925–2011): You never stopped believing in research. We are all indebted to you.

Preface

Patients usually refer to the doctor complaining of a symptom but the vast majority of medical textbooks focus on diseases rather than on symptom management. Therefore, it follows that a symptom-oriented approach probably best reflects the correct patient/physician interaction in all fields of clinical medicine. Symptoms like dyspnoea, sneezing and cough are normal behavioural responses brought about by changes in the physiological milieu of the respiratory tract. These symptoms are not pathological conditions per se, as they may be in the case of pain; however, when they persist and/or are troublesome, they may become intolerable and result in severe worsening of the patient’s quality of life. Chronic cough, that is a cough lasting longer than eight weeks, is among the most common respiratory symptoms for which patients seek medical advice. It has long been recognised that virtually all diseases of the respi