Crohn's Disease Current Concepts

Presenting recent advances related to inflammatory bowel disease as well as imaging of the intestine through CT, MR Enterography, diffusion and perfusion imaging, tissue harmonic imaging, capsule endoscopy and push enteroscopy amongst others, Crohn’s Dise

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Crohn’s Disease Current Concepts

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Crohn’s Disease

Arumugam Rajesh • Rakesh Sinha Editors

Crohn’s Disease Current Concepts

Editors Arumugam Rajesh University Hospitals of Leicester NHS Trust Leicester, UK

Rakesh Sinha Department of Radiology Warwick Hospital Warwick, UK

ISBN 978-3-319-01912-3 ISBN 978-3-319-01913-0 DOI 10.1007/978-3-319-01913-0 Springer Cham Heidelberg New York Dordrecht London

(eBook)

Library of Congress Control Number: 2014957531 © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Dedicated with love to my parents Suresh and Saraswati Sinha Rakesh Sinha Dedicated with love to my parents, R. A. Mudaliar and Suseela Arumugam My wife and daughters Priya, Nethra and Unnathi And In memory of my friend Dr. Madhusudanan Sriperumbudur Arumugam Rajesh

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Foreword

The Times They Are A-Changin’ – Bob Dylan

Medical historians [1–3] have suggested that the initial description of Crohn’s disease may have dated back to Morgagni [4]. Despite new knowledge from immunology, molecular biology, molecular genetics, and other disciplines, this disease ranks as one of the major clinical enigmas of medicine, challenging all scientific disciplines. It is classified medically as an autoimmune disorder, bu