Nuclear Receptors Current Concepts and Future Challenges
In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient’s condition. A few years later, medications for the then ill-explained condition of the menopause included tablets
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Acute promyelocytic leukemia, 352 Adipose tissue, 66, 92, 103, 156, 259, 262–263, 266–273, 309, 320, 390, 397–399, 405 Androgen, 6, 68, 74, 105, 114, 143–177, 220, 225, 345, 366, 368–370, 372–373 Androgen receptor, 74, 105, 114, 143–177, 220, 328, 369–370, 372–373, 397, 399 Antiandrogen, 145–146, 157, 159–160, 164–165, 170 Anti cancer drugs, 399 11β-hydroxysteroid dehydrogenase, 66, 396, 398, 401 Bile acid, 23, 206, 226, 238, 288, 290–292, 294–295, 307–311, 313–320, 404 Bioinformatics, 226, 419, 430, 450 Bone, 92, 103, 105–107, 144–145, 157, 159, 164–166, 190–192, 210–212, 214, 224, 226, 333, 336–339, 402 Breast cancer, 93, 113–115, 216, 222–225, 250, 320, 356, 368 Brg-1, 348–351, 356 Calcium, 103, 153, 204–208, 210–214, 226, 335, 337–338, 370, 425 Cancer, 64, 78, 80, 92–92, 113–115, 145–146, 152–153, 157, 159–160, 164–166, 216–220, 222–225, 247, 249–250, 309, 318–320, 356, 366–370, 398–399, 406 CAR, 21, 238, 287–297, 316–317, 420, 424 Cellular proliferation, 110, 114, 205, 215, 222, 226, 249–250, 370, 372, 402 Central nervous system, 50, 64, 111–112, 144, 164, 329–332 Chemoprevention, 217, 219–220, 249–250 Chemotherapy, 217, 219–220, 242, 247–248 Chip-chip, 356, 425–426 Chip-seq, 356, 420, 425–426, 429, 431 Cholestasis, 290, 309, 315–316 Chromatin, 8–9, 68–70, 95, 100, 187, 207–208, 218, 239–241, 261, 345–357, 374, 420–425, 427–428, 430
Chromatin remodeling, 68, 207–208, 345–357, 374, 406, 423 Classification, 5, 7, 16–17, 34, 47, 51, 190, 205, 421, 424 Coactivators, 19, 66, 68–71, 76, 79, 98, 100, 187, 239–241, 260–262, 290–291, 293, 297 Computational biology, 419 Corepressors, 66, 70, 98–100, 186–187, 239–241, 246, 260, 293 Cross-talk between growth factors and steroids, 375 Crystallography, 150, 169 Cytochrome p450, 7, 204, 242–243, 288, 310, 396–397, 400, 402, 404 Deiodinases, 186, 405–406 Development, 3–4, 6, 31–51, 64–65, 93, 103–111, 115, 145, 160, 164, 177, 187, 192, 194, 210–211, 213, 226, 250, 265, 271–272, 294, 328–333, 339 Diet, 108–109, 203, 212–214, 216–217, 226, 316–319, 395 Differentiation, 3, 20, 38, 47, 50–51, 144, 208, 215–216, 219, 240, 243–245, 270, 332, 336, 406 Drosophila melanogaster, 33–34, 37, 40 Drug metabolism, 289 Enterohepatic circulation, 310, 313–314, 404 Epidemiology, 216, 220, 320 Epigenetic, 113–114, 224, 247–248, 352–353, 422, 426 Estradiol receptors, 367–369, 372 Estrogen receptor beta, 369 Evolution, 2, 11, 15–25, 33, 43–44, 49, 205–206, 390, 420, 431 Extra-nuclear and nuclear action integration, 374–375 Fertility, 50, 104–105, 192, 213, 329–330, 339 Fibrates, 262 Free-hormone, 383
455 C.M. Bunce, M.J. Campbell (eds.), Nuclear Receptors, Proteins and Cell Regulation 8, 455–457. DOI 10.1007/978-90-481-3303-1, C Springer Science+Business Media B.V. 2010
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INDEX
FXR, 34, 36, 206, 226, 238, 294–295, 307–320 Gene expression, 2, 7–9, 36, 46, 51, 67–69, 76–77, 79–80, 100–102, 109–110, 186, 248, 264, 273, 291–295, 318, 333, 374 Glucocorticoid Receptor, 3–4, 9, 63–80, 265, 295, 398 Glucose, 63–64, 68, 107–108, 191, 264, 270, 288, 307–308, 312–313, 317, 320, 332–333 HCC, 113 He
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