Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for su
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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules The Shape of Organic Synthesis to Come
Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules
Yuichi Kobayashi Editor
Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules The Shape of Organic Synthesis to Come
Editor Yuichi Kobayashi Department of Biotechnology Tokyo Institute of Technology Yokohama, Japan
ISBN 978-981-13-6243-9 ISBN 978-981-13-6244-6 (eBook) https://doi.org/10.1007/978-981-13-6244-6 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
The purpose of organic synthesis is to provide target compounds by selective methods with high optical purity. Many transition metal-catalyzed asymmetric reactions and reactions catalyzed by organocatalysts have been developed to efficiently reach the goals. Reducing and oxidizing reagents that are highly chemoselective and/or environmentally friendly are also indispensable tools toward the purpose. On the other hand, analytical techniques have advanced to allow swift determination of the efficiency of reactions and the structures. For example, LC-MS analysis equipped with a chiral column could determine the chirality of the structure. Such new reactions and the advances in analytical techniques produced new power for organic synthesis to foray into fields, which used to be considered out of organic synthesis. As a consequence, many interdisciplinary areas have emerged, attracted attention of chemists, and rapidly grown. This book was planned to grasp the latest and excellent achievements in organic synthesis, which are expected to be grown mor
