Cyclin-Dependent Kinase (CDK) Inhibitors Methods and Protocols
This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describ
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Mar Orzáez Mónica Sancho Medina Enrique Pérez-Payá Editors
Cyclin-Dependent Kinase (CDK) Inhibitors Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cyclin-Dependent Kinase (CDK) Inhibitors Methods and Protocols Edited by
Mar Orzáez Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain
Mónica Sancho Medina Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain
Enrique Pérez-Payá IBV-CSIC and Centro de Investigacion Príncipe Felipe, Valencia, Spain
Editors Mar Orzáez Medicinal Chemistry Centro de Investigación Príncipe Felipe Valencia, Spain
Mónica Sancho Medina Medicinal Chemistry, Centro de Investigación Príncipe Felipe Valencia, Spain
Enrique Pérez-Payá IBV-CSIC and Centro de Investigacion Príncipe Felipe Valencia, Spain
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2925-2 ISBN 978-1-4939-2926-9 (eBook) DOI 10.1007/978-1-4939-2926-9 Library of Congress Control Number: 2015944984 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media, LLC 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Proliferation of eukaryotic cells is under control of a series of concerted molecular mechanisms defined as the cell division cycle whose progression is tightly governed by members of the cyclin-dependent kinase family (CDKs). At different phases of the cell cycle, the CDKs associate with specific cyclins. These particular CDK/cyclin pairs preferentially phosphorylate sets of largely distinct substrates triggering the progression through the cell cycle phases. For example, CDK2/cyclin E mediated
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