ATM Kinase Methods and Protocols
Ataxia–telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and cancer predisposition. This detailed volume explores the ever expanding
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Sergei V. Kozlov Editor
ATM Kinase Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
ATM Kinase Methods and Protocols
Edited by
Sergei V. Kozlov University of Queensland Centre for Clinical Research (UQCCR), University of Queensland, Herston, QLD, Australia
Editor Sergei V. Kozlov University of Queensland Centre for Clinical Research (UQCCR) University of Queensland Herston, QLD, Australia
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6953-1 ISBN 978-1-4939-6955-5 (eBook) DOI 10.1007/978-1-4939-6955-5 Library of Congress Control Number: 2017936986 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children. Since the discovery and cloning of the ATM (ataxia-telangiectasia, mutated) gene causing the disease in 1995, A-T has become an ever expanding field of research that has been enriched by contributions from the broad community of scientists attracted to the field by the fundamental role played by the ATM kinase in DNA damage signaling and diverse cellular processes. This has led to the development of a great number of protocols related to studies of the ATM gene and protein, which have been scattered across many published papers and books, including the Methods in Molecular Biology series. It is a timely undertaking by the Methods in Molecular Biology program to c
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