Cycloadditions in Bioorthogonal Chemistry

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related discipline

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Milan Vrabel Thomas Carell Editors

Cycloadditions in Bioorthogonal Chemistry

Topics in Current Chemistry Collections

Journal Editors Massimo Olivucci, Siena, Italy and Bowling Green, USA Wai-Yeung Wong, Hong Kong Series Editors Hagan Bayley, Oxford, UK Kendall N. Houk, Los Angeles, USA Greg Hughes, Codexis Inc, USA Chris Hunter, Cambridge, UK Kazuaki Ishihara, Nagoya, Japan Michael J. Krische, Austin, Texas Jean-Marie Lehn, Strasbourg, France Rafael Luque, Córdoba, Spain Jay S. Siegel, Tianjin, China Joachim Thiem, Hamburg, Germany Margherita Venturi, Bologna, Italy Chi-Huey Wong, Taipei, Taiwan Henry N.C. Wong, Hong Kong Vivian Wing-Wah Yam, Hong Kong Chunhua Yan, Beijing, China Shu-Li You, Shanghai, China

Aims and Scope The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. More information about this series at http://www.springer.com/series/14181

Milan Vrabel • Thomas Carell Editors

Cycloadditions in Bioorthogonal Chemistry With contributions from T. Carell • P. R. Chen • F. L. van Delft • N. K. Devaraj J. Dommerholt • A. Herner • S. Kath-Schorr • Q. Lin F. P. J. T. Rutjes • M. Vrabel • H. Wu • M. Yang • Y. Yang

Editors Milan Vrabel Department of Bioorganic and Medicinal Chemistry Institute of Organic Chemistry and Biochemistry Prague, Czech Republic

Thomas Carell Department of Chemistry and Pharmacy Ludwig-Maximilians University Munich Munich, Germany

Originally published in Top Curr Chem (Z) Volume 374 (2016), © Springer International Publishing Switzerland 2016 ISSN 2367-4067 ISSN 2367-4075 (electronic) Topics in Current Chemistry Collections ISBN 978-3-319-29684-5 ISBN 978-3-319-29686-9 (eBook) DOI 10.1007/978-3-319-29686-9 Library of Congress Control Number: 2016942484 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illus