CYP2E1 T7632A and 9-bp insertion polymorphisms and colorectal cancer risk: a meta-analysis based on 4,592 cases and 5,91
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RESEARCH ARTICLE
CYP2E1 T7632A and 9-bp insertion polymorphisms and colorectal cancer risk: a meta-analysis based on 4,592 cases and 5,918 controls Jun Qian & Zhangfa Song & Yinxiang Lv & Xuefeng Huang
Received: 11 February 2013 / Accepted: 22 March 2013 / Published online: 1 May 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013
Abstract Previous studies suggest that genetic factors play important roles in the development of colorectal cancer. CYP2E1 T7632A and 9-bp insertion polymorphisms may influence the risk of colorectal cancer, but published results are conflicting. We therefore conducted a meta-analysis comprising 9 case–control studies with 4,592 cases and 5,918 controls. Odds ratios (ORs) with 95 % confidence interval (95 % CI) were used to assess the strength of the associations of CYP2E1 T7632A and 9-bp insertion polymorphisms with colorectal cancer. For CYP2E1 T7632A polymorphism, meta-analysis showed that there was no significant association between the CYP2E1 T7632A polymorphism and colorectal cancer risk under all contrast models (A vs. T: OR=1.06, 95 % CI 0.88–1.29, P=0.528; AA vs. TT: OR = 0.85, 95 % CI 0.61–1.19, P= 0.351; AA/TA vs. TT: OR=1.08, 95 % CI 0.87–1.34, P=0.484; and AA vs. TT/TA: OR=0.87, 95 % CI 0.62–1.21, P=0.395). For CYP2E1 96-bp insertion polymorphism, meta-analysis showed that there was a significant association between the CYP2E1 96-bp insertion polymorphism and colorectal cancer risk under the allele contrast model and the dominant contrast model (for the allele contrast model: OR=1.20, 95 % CI 1.06–1.36, P=0.005; for the dominant contrast model: OR=1.25, 95 % CI 1.07–1.45, P=0.005). Subgroup analysis by race suggested that there was an obvious association J. Qian : Y. Lv Department of Colorectal Surgery, Xinchang People’s Hospital, Zhejiang Province, Xinchang 312500, China Z. Song (*) : X. Huang Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 Qinchun East Road, Hangzhou 310016, China e-mail: [email protected]
between the CYP2E1 96-bp insertion polymorphism and colorectal cancer risk in Asians under the codominant contrast model. In conclusion, our meta-analysis demonstrates that there is a significant association between the CYP2E1 96-bp insertion polymorphism and colorectal cancer risk, and CYP2E1 9-bp insertion polymorphism is a risk factor for developing colorectal cancer. Keywords CYP2E1 . Polymorphism . Colorectal cancer . Meta-analysis
Introduction Colorectal cancer is one of the most common cancers in both developed countries and developing countries [1, 2]. Colorectal cancer has been a public concern getting more and more attentions for its poor prognosis. Though the definite mechanism of its development is still unknown, it has been well accepted that both genetic and environmental factors are involved in the onset of colorectal cancer [3, 4]. Previous studies suggest that genetic factors play important roles in the development of colorectal cancer, and many genetic polymorphisms are proven associated
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