Polymorphisms in genes of APE1 , PARP1 , and XRCC1 : risk and prognosis of colorectal cancer in a Northeast Chinese popu
- PDF / 195,507 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 5 Downloads / 208 Views
SHORT COMMUNICATION
Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a Northeast Chinese population Ye Li • Shuying Li • Zhiwei Wu • Fulan Hu • Lin Zhu • Xiaojuan Zhao Binbin Cui • Xinshu Dong • Suli Tian • Fan Wang • Yashuang Zhao
•
Received: 22 December 2012 / Accepted: 8 February 2013 / Published online: 22 February 2013 Ó Springer Science+Business Media New York 2013
Abstract Base excision repair (BER) pathway plays critical role in maintaining genome integrity. Polymorphisms in BER genes which modulate the DNA repair capacity may affect the susceptibility and prognosis of cancer. We conducted a case–control study and followed up the cases to explore the associations between BER genes polymorphisms and the risk and prognosis of colorectal cancer (CRC). This study included 451 CRC patients and 631 controls. Four single-nucleotide polymorphisms (SNPs) in genes of apurinic/apyrimidinic endonuclease-1 (APE1), ADP-ribosyltransferase (ADPRT, also known as PARP1), and X-ray repair cross-complementing groups 1 (XRCC1) were tested by PCR–RFLP. Odds ratio (OR), hazard ratio (HR), and their 95 % confidence intervals (CIs) were calculated by unconditional logistic regression and Cox proportional hazard model. PARP1 762 recessive model (OR = 1.57, 95 % CI 1.12–2.20) and XRCC1 194 dominant model (OR = 1.45, 95 % CI 1.12–1.88) were associated with increased CRC risk. A significant increasing trend for the risk of CRC was detected with the increasing number of putative risk Y. Li S. Li Z. Wu F. Hu L. Zhu X. Zhao F. Wang (&) Y. Zhao (&) Department of Epidemiology, Public Health College, Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, People’s Republic of China e-mail: [email protected] Y. Zhao e-mail: [email protected]; [email protected] B. Cui Department of Colorectal Surgery, Cancer Hospital of Harbin Medical University, Harbin, People’s Republic of China X. Dong S. Tian Department of Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
genotypes (Ptrend = 0.00). However, no association was found between these four SNPs and the prognosis of CRC. In conclusion, APE1 (Asp148Glu), PARP1 (Ala762Val), and XRCC1 (Arg399Gln, Arg194Trp) were associated with the susceptibility to CRC, but were not associated with the prognosis of CRC. Keywords Colorectal cancer Single-nucleotide polymorphism Base excision repair Risk Prognosis
Introduction Colorectal cancer (CRC) is the third most commonly cancer and the fourth most frequent cause of cancer death worldwide [1]. The majority of patients diagnosed with CRC are no longer confined to the primary site, and the 5-year survival rate of metastatic CRC is below 10 % [2]. Base excision repair (BER) pathway specifically removes the alterations in a single base that has been methylated, oxidized, or reduced and thus rectifies single-strand interruptions in DNA [3]. Few studies investigated the associations between APE1 Asp148Glu and CRC risk,
Data Loading...
