Cytocompatibility Evaluation of Ti-6Al-4V Alloy After Gas Oxynitriding
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Cytocompatibility Evaluation of Ti-6Al-4V Alloy After Gas Oxynitriding I.M. Pohrelyuk, O.V. Tkachuk, R.V. Proskurnyak, N.M. Boiko, O.Yu. Kluchivska, R.S. Stoika, and P. Ozga Submitted: 1 June 2020 / Revised: 20 September 2020 / Accepted: 6 October 2020 The oxynitriding of Ti-6Al-4V alloy was realized by thermodiffusion saturation of non-stoichiometric titanium nitride by oxygen (P(O2) = 1023 to 1 Pa). The oxygen content in TiNxO12x increased by increasing P(O2) and it led to transformation into TiO2 as follows: TiN0.46O0.54 fi TiN0.42O0.58 fi TiN0.36O0.64 + TiO2. It caused an increase in the viability of pseudonormal human cells of HEK293T line after 8 days of testing. TiN0.36O0.64 + TiO2 coating exhibited normal morphology and provided 1.2-fold higher cytocompatibility compared to Ti-6Al-4V alloy. This coating can be recommended for further in-depth testing as bio-implant material. Keywords
cytocompatibility, oxynitriding, pseudonormal human cells, Ti-6Al-4V alloy
1. Introduction A wide range of various biomaterials for traumatology, orthopedics and dentistry is being actively developed in the world. Titanium and Ti-6Al-4V titanium alloy are the most popular and commonly used in medicine because they have several advantages over other metallic biomaterials: high biocompatibility and corrosion resistance, etc. (Ref 1-5). However, the use of Ti-6Al-4V alloy for the implant manufacture can lead to tissue intoxication due to metal ion release of alloying elements (Ref 6, 7). Therefore, there is the growing interest in surface engineering of titanium implants to enhance their cell adhesion and tissue integration. Currently, many techniques such as magnetron sputtering (Ref 8, 9), multi-arc ion plating (Ref 10), anodization (Ref 11), arc evaporation (Ref 12), glow-plasma discharge (Ref 12, 13) and CVD (Ref 14) have been applied to improve the performance of Ti-6Al-4V alloy for implant applications. Li et al. (Ref 8) found that a-C/aC:Ti nanomultilayer films coated Ti-6Al-4V exhibited good biocompatibility as an implant material. Cho et al. (Ref 14) reported that 150 nm a-C coating deposited on Ti-6Al-4V substrate demonstrated the lower corrosion resistance, higher cell viability and biocompatibility as compared to bare alloy. TiN deposited on Ti-6Al-4V alloy using a high-power impulse magnetron sputtering exhibits great polarization resistance in simulated body fluid and shows excellent cell viability of
I.M. Pohrelyuk, O.V. Tkachuk, and R.V. Proskurnyak, Karpenko Physico-Mechanical Institute of National Academy of Sciences of Ukraine, 5, Naukova Str., Lviv 79060, Ukraine; N.M. Boiko, O. Yu. Kluchivska, and R.S. Stoika, Institute of Cell Biology of National Academy of Sciences of Ukraine, 14/16, Dragomanov Str., Lviv 79005, Ukraine; and P. Ozga, Institute of Metallurgy and Materials Science of Polish Academy of Sciences, 25, W. Reymonta Str., 30-059 Krako´w, Poland. Contact e-mail: [email protected].
Journal of Materials Engineering and Performance
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