Cytotoxicity and antibacterial efficacy of silver deposited onto titanium plates by low-energy ion implantation
- PDF / 478,110 Bytes
- 9 Pages / 584.957 x 782.986 pts Page_size
- 12 Downloads / 164 Views
This section of Journal of Materials Research is reserved for papers that are reviews of literature in a given area.
Cytotoxicity and antibacterial efficacy of silver deposited onto titanium plates by low-energy ion implantation Tatiana P. Soares Área do Conhecimento de Ciências Exatas e Engenharias, Universidade de Caxias do Sul, Caxias do Sul, RS 95070-560, Brazil
Charlene S.C. Garcia and Mariana Roesch-Ely Instituto de Biotecnologia, Universidade de Caxias do Sul, Caxias do Sul, RS 95070-560, Brazil
Marcelo E.H. Maia da Costa Departamento de Física, Pontifícia Universidade Católica, Rio de Janeiro, RJ 22453-900, Brazil
Marcelo Giovanela and Cesar Aguzzolia) Área do Conhecimento de Ciências Exatas e Engenharias, Universidade de Caxias do Sul, Caxias do Sul, RS 95070-560, Brazil (Received 28 March 2018; accepted 4 June 2018)
Contamination by bacterial biofilms has a strong negative impact, especially on the surface of prostheses, implants, pins, and other medical-surgical devices. To prevent their formation, one of the alternatives is the modification of the metal surface incorporating silver by low-energy ion implantation, thus avoiding initial bacteria adhesion to the modified surface and further development of the biofilm. The bactericidal properties of silver atoms incorporated on commercially pure titanium surfaces by low-energy ion implantation (4 keV) were evaluated. The surface modifications were analyzed by Rutherford backscattering spectrometry, glow dischargeoptical emission spectroscopy, contact angle measure, optical profilometry, and X-ray photoelectron spectroscopy. The microbiological assays were conducted by using Escherichia coli (E. coli). The results demonstrated a reduction on bacterial counting. No toxic effect of silver was detected on human MG-63 cells. The choice of parameters to obtain a bactericidal and nontoxic biomaterial for human cells should consider the ideal combination “energy 1 silver concentration”. Therefore, it can be considered for industrial application.
I. INTRODUCTION
Titanium and its alloys are often used as biomedical implants owing to their excellent mechanical properties, such as their relatively low modulus, excellent fatigue strength, and formability.1,2 Another property is its biocompatibility, considering that titanium is biologically inert and corrosion resistant due to the thin oxide layer of titanium oxide (TiO2), which forms automatically on its surface. For these reasons, titanium is commonly used in biomedicine, for example, in hip and knee prostheses or dental implants.3,4 However, biofilms often form on the surface of these materials. Biofilms are highly organized biological systems composed of different types of micro-organisms, mainly bacteria, which first adhere individually on a surface, before expanding and maturating, thus producing a matrix of extracellular polymeric substances that makes the a)
Address all correspondence to this author. e-mail: [email protected] DOI: 10.1557/jmr.2018.200 J. Mater. Res., 2018
colonies highly resistant to antibiotics. I
Data Loading...
