Decoding Neural Circuit Structure and Function Cellular Dissection U
This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory syst
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Decoding Neural Circuit Structure and Function Cellular Dissection Using Genetic Model Organisms
Decoding Neural Circuit Structure and Function
Arzu Çelik Mathias F. Wernet •
Editors
Decoding Neural Circuit Structure and Function Cellular Dissection Using Genetic Model Organisms
123
Editors Arzu Çelik Department of Molecular Biology and Genetics Boğaziçi University Bebek, Istanbul Turkey
ISBN 978-3-319-57362-5 DOI 10.1007/978-3-319-57363-2
Mathias F. Wernet Fachbereich Biologie, Chemie, Pharmazie, Institut für Biologie—Neurobiologie Freie Universität Berlin Berlin Germany
ISBN 978-3-319-57363-2
(eBook)
Library of Congress Control Number: 2017940534 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
We Live in Exciting Times We live in exciting times. Blocking or activating single cell types and recording from them in the awake behaving animal has so much become standard that one could almost forget that it has not always been this way. In fact, it is only about 20 years ago that the usual way to establish structure–function relationship‚ e.g.‚ in Drosophila was to screen randomly generated mutants. If the screen was a structural one, it was followed by behavioral tests, if the screen was a behavioral one, it was followed by a structural study. Much brain power went into ingenious design of these screens as well as in the elegant behavioral setups, many of them are still in use today. While the results obtained this way were certainly an interesting first step, they suffered from important limitations insurmountable at that time. First of all, the resolution one obtained was a course
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