Degradation control of cellulose scaffold by Malaprade oxidation
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Degradation control of cellulose scaffold by Malaprade oxidation Wichchulada Konkumnerd 1,2, Suong-Hyu Hyon3, Kazuaki Matsumura1 1
School of Materials Science, Japan Advanced Institute of Science and Technology, Japan
2
Facalty of Science, Chulalongkorn University, Thailand
3
Center for Fiber and Textile Science, Kyoto Institute of Technology, Japan
ABSTRACT Study on oxidizing cellulose scaffold to dialdehyde cellulose by sodium periodate (NaIO4) was carried out. Concentration of sodium periodate and the reaction time were effected for aldehyde introduction to cellulose scaffolds. Cellulose powder was dissolved in 1-butyl-3methylimidazolium chloride, an ionic liquid, at 100°C and maintained at room temperature for 7 days, providing flexible cellulose scaffold. The cellulose scaffold was oxidized using periodate oxidation (Malaprade oxidation), which oxidizes carbohydrate by glycol cleavage to provide dialdehyde. Aldehyde groups introduced into cellulose were quantified by simple iodometry. Oxidized cellulose scaffold was degraded in the amino acid solution triggered by the reaction between aldehyde groups and amino groups. During immersion of the cellulose scaffolds in the amino acid solution, the mass loss of the scaffolds was evaluated by measuring of weight of oxidized cellulose scaffold before and after degradation.
INTRODUCTION Tissue engineering is most usually assigned as the application of medical science and engineering principles in the design, erection, interpolation, growth and maintenance of living tissues. Normally, a three-dimensional structure, called scaffold, is necessary in tissue engineering applications since bioartificial tissues involve three-dimensional structures with cell multitude [1]. The evolution of the field of tissue engineering goes in parallel with the coherent demand for new scaffolding materials with definite properties such as controlled porosity and pore size distribution, biocompatibility and biodegradation. Among these materials, natural polymers predispose especially interest because of their biocompatibility, biodegradation, and exuberance. Polysaccharides are natural polymers that include cellulose, chitin, and starch. Cellulose is the most abundant polysaccharide found on earth, but cellulose has many limitations in utilization and manipulation such as its poor solubility in water or organic solvent, its solution is highly viscous and present gel formation ability. When a variety of cellulose derivative are produced, the oxidation is very important way [2,3]. Oxidation cellulose cause change in the structure and crystallinity of the results molecule, which affect its chemical and physical
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properties [4-6]. The oxidation can lead to a variety of polymer with difference functional group, so this can increase the range of cellulose application. We found that aldehyde introduced polysaccharide via Malaprade oxidation can be degraded at the glycoside bonds through the reaction with amino groups. In this study, we focus on the control of cellulose scaffolds degrada
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