Determinants of periodontitis according to the immunological and virological profiles of HIV-infected patients in Yaound
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RESEARCH ARTICLE
Open Access
Determinants of periodontitis according to the immunological and virological profiles of HIV‑infected patients in Yaoundé, Cameroon Joseph Fokam1,2,3*, Buolikeze Kuoh Nji Geh1,2*, Samuel Martin Sosso1, Desire Takou1, Ezechiel Semengue Ngufack1, Alex Durand Nka1, Anne‑Cecile Z.‑K. Bissek1,2,4, David Mindja Eko2 and Alexis Ndjolo1,2
Abstract Background: HIV infection is associated to different oral manifestations (including periodontal diseases), which have decreased with the advent of antiretroviral therapy (ART). Yet, the occurrence of periodontitis is still consistent among patients with HIV living in sub Saharan-Africa, with limited evidence on the driven factors and mitigating measures in these settings. We aimed at evaluating the occurrence of periodontitis and its associated immunological and virologi‑ cal factors in patients with HIV living in Yaoundé, Cameroon. Methods: We included 165 (44 ART-naïve and 121 ART-experienced) patients > 18 years old attending the Yaoundé Central Hospital and the Chantal BIYA International Reference Centre, from January-April 2018. The periodontal status was assessed by measuring the clinical attachment loss, periodontal pocket depth, plaques index and gingival bleed‑ ing index. CD4+/CD8+ cells and viremia were measured using the fluorescence-activated cell sorting method (FACS Calibur) and the Abbott m2000 RT HIV-1 RNA kit respectively. A standard-questionnaire concerning participants’ medi‑ cal records and oral hygiene methods was filled. Data was analyzed and p
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