Development of Biodegradable Polyphosphazene- Nanohydroxyapatite Composite Nanofibers Via Electrospinning
- PDF / 4,575,736 Bytes
- 6 Pages / 612 x 792 pts (letter) Page_size
- 90 Downloads / 227 Views
AA4.2.1
Development of Biodegradable Polyphosphazene- Nanohydroxyapatite Composite Nanofibers Via Electrospinning Subhabrata Bhattacharyya1, Lakshmi S. Nair2, Anurima Singh3 , Nick R. Krogman3, Jared Bender3, Yaser E.Greish4, Paul W. Brown4, Harry R. Allcock3, Cato T. Laurencin2,5,6,* 1
Department of Chemistry, The University of Virginia, Charlottesville, VA-22903 Department of Orthopaedic Surgery, The University of Virginia, Charlottesville, VA-22903 3 Department of Chemistry, The Pennsylvania State University, PA-16802, 4Intercollege Materials Research Laboratory, The Pennsylvania State University, PA, PA-16802 5 Department of Chemical Engineering, The University of Virginia, Charlottesville, VA-22904 6 Department of Biomedical Engineering, The University of Virginia, Charlottesville, VA-22908 2
*Corresponding Author Cato T. Laurencin M.D., Ph.D. University Professor, Lillian T. Pratt Distinguished Professor and Chair of Orthopaedic Surgery Professor of Biomedical and Chemical Engineering The University of Virginia 400 Ray C. Hunt Drive, Suite 330 Charlottesville, VA 22903 Office: (434) 243-0250 Fax: (434) 243-0252 Email: [email protected] ______________________________________________________________________________ Abstract Biodegradable polymeric nanofibers are of great interest as scaffolds for tissue engineering and drug delivery due to their extremely high surface area, high aspect ratio and similarity in structure to the extracellular matrix (ECM). Polyphosphazenes due to their synthetic flexibility, wide range of physico-chemical properties, non-toxic and neutral degradation products and excellent biocompatibility are suitable candidates for biomedical applications. The objective of the present study was to develop and evaluate composite nanofibers of a biodegradable polyphosphazene, poly[bis(ethyl alanato)phosphazene] (PNEA) and nanocrystals of hydroxyapatite (nHAp) via electrospinning. A suspension of nHAp in dimethyl formamide (DMF) sonicated with PNEA solution in tetrahydrofuran (THF) was used to develop composite nanofiber matrices via electrospinning at ambient conditions. In the present study the theoretical loading of nHAp was varied from 50%-90% (w/w) to PNEA. The nHAp content (actual loading of nHAp) of the composite nanofibers was determined by gravimetric estimation. The composite nanofibers were characterized by transmission electron microscopy (TEM), gravimetry and energy dispersive X-ray mapping. This study demonstrated the feasibility of developing novel composite nanofibers of biodegradable polyphosphazenes with more than 50% (w/w) loading of nHAp on and within the nanofibers. Keywords: Polyphosphazenes, Bone tissue engineering, Electrospinning, Nanofiber, Nanohydroxyapatite.
AA4.2.2
Introduction Tissue engineering is defined as the application of biological, chemical and engineering principles toward the repair, restoration or regeneration of living tissues using biomaterials, cells and factors, alone or in combination [1]. This approach is emerging as an alternative therapeuti
Data Loading...
