Development of Subunit Vaccines for Group A Streptococcus
There is currently no available vaccine to prevent infection with Streptococcus pyogenes (also known as group A streptococcus, GAS), which can lead to the life-threatening diseases rheumatic fever (RF) and rheumatic heart disease (RHD). RF and RHD occur w
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Molecular Vaccines
From Prophylaxis to Therapy - Volume 1
Molecular Vaccines
Matthias Giese Editor
Molecular Vaccines From Prophylaxis to Therapy Volume 1
Editor Matthias Giese, PhD Institute for Molecular Vaccines Heidelberg Germany
ISBN 978-3-7091-1418-6 ISBN 978-3-7091-1419-3 DOI 10.1007/978-3-7091-1419-3 Springer Wien Heidelberg Dordrecht London New York
(eBook)
Library of Congress Control Number: 2013948891 © Springer-Verlag Wien 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Mens agitat molem.
To my children Geraldine, Sebastian and Laura, who make everything worthwhile.
Preface
The idea of this book was born out of rage. I am developing vaccines for more than 20 years – a troublesome and laborious business. It can be troublesome because pure theory and successful application of a theory in lab models, and later its translation into clinical practice, are poles apart. And it can be laborious because until now there is no complete scientific compendium covering all essential aspects of modern vaccine development in one book, what makes the busy normal lab day more difficult for a developer. A developer is obliged to read several textbooks: You will need one book to understand all immunological key aspects; to learn the way of presentation
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