Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy
- PDF / 731,265 Bytes
- 10 Pages / 595.22 x 842 pts (A4) Page_size
- 111 Downloads / 240 Views
911
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.jzus.zju.edu.cn; www.springerlink.com E-mail: [email protected]
Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy*# Xiao-hong WU§1, Jing-wen FANG§2, Yin-qiong HUANG1, Xue-feng BAI1, Yong ZHUANG1, Xiao-yu CHEN1, Xia-hong LIN†‡1 1
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China 2
Department of Endocrinology, the First Hospital of Quanzhou, Quanzhou 362000, China †
E-mail: [email protected]
Received Apr. 30, 2020; Revision accepted Aug. 5, 2020; Crosschecked Oct. 15, 2020
Abstract: Objective: To investigate the value of optic disc retinal nerve fiber layer (RNFL) thickness in the diagnosis of diabetic peripheral neuropathy (DPN). Methods: Ninety patients with type 2 diabetes, including 60 patients without DPN (NDPN group) and 30 patients with DPN (DPN group), and 30 healthy participants (normal group) were enrolled. Optical coherence tomography (OCT) was used to measure the four quadrants and the overall average RNFL thickness of the optic disc. The receiver operator characteristic curve was drawn and the area under the curve (AUC) was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN. Results: The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average ((101.07± 12.40) µm vs. (111.07±6.99) µm and (109.25±6.90) µm), superior quadrant ((123.00±19.04) µm vs. (138.93±14.16) µm and (134.47±14.34) µm), and inferior quadrant ((129.37±17.50) µm vs. (143.60±12.22) µm and (144.48±14.10) µm), and the differences were statistically significant. The diagnostic efficiencies of the overall average, superior quadrant, and inferior quadrant RNFL thicknesses, and a combined index of superior and inferior quadrant RNFL thicknesses were similar, and the AUCs were 0.739 (95% confidence interval (CI) 0.635–0.826), 0.683 (95% CI 0.576–0.778), 0.755 (95% CI 0.652–0.840), and 0.773 (95% CI 0.672–0.854), respectively. The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%. Conclusions: The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN. Key words: Type 2 diabetes; Peripheral neuropathy; Retinal nerve fiber layer thickness; Optical coherence tomography; Diagnosis https://doi.org/10.1631/jzus.B2000225 CLC number: R587.1
1 Introduction
‡
Corresponding author § The two authors contributed equally to this work * Project supported by the Science and Technology Plan Project of Quanzhou (Nos. 2018Z114, 2018Z115, and 2019N104S), the Qihang Fund of Fujian Medical University (No. 2016QH072), and the Health Research Talent Training Project of Fujian (No. 2019-ZQN-66), China # Electronic supplementary materials: The online version of this article (https://doi.org/10.1631/jzus.B2000225) contains supplementary materials, which are available to a
Data Loading...
