Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report
- PDF / 3,119,277 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 98 Downloads / 190 Views
CASE REPORT
Open Access
Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report Jing Li1†, Gang Chen1†, Mingmin Zhang1, Shenghao Tu1 and Chao Chen2*
Abstract Background: The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 has spread rapidly worldwide and disease spread is currently increasing. Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive therapy on COVID-19 infection are lacking. Case presentation: We report two cases of COVID-19 infection in renal transplant recipients with variable clinical presentations. The first patient presented with mild respiratory symptoms and a stable clinical course. The second patient had more severe clinical characteristics and presented with severe pneumonia and multi-organ failure. Both patients received a combination therapy including antiviral treatment and reduced immunosuppression therapy and finally recovered. Conclusions: We report COVID-19 infection in two renal transplant recipients with a favorable outcome but different clinical courses, which may provide a reference value for treating such patients. Keywords: Coronavirus disease 2019, Acute respiratory syndrome coronavirus 2, Renal transplant recipients, Immunosuppressive therapy, Case report
Background As of early-May 2020, Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) has expanded to include over 3, 884,000 confirmed cases and over 272, 000 deaths, involving 176 countries around the world. The COVID-19 outbreak is spreading worldwide and has become a major international concern. On March 11, the World Health Organization (WHO) upgraded the status of the COVID-19 outbreak from epidemic to pandemic. Patients with COVID-19 may develop severe symptoms of acute respiratory infection, particularly * Correspondence: [email protected] † Jing Li and Gang Chen contributed equally to this work. 2 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China Full list of author information is available at the end of the article
those with comorbid conditions tend to have a high mortality rate [1]. Thus far, there are no specific therapeutic agents for COVID-19, and supportive care is the mainstay of management strategies. Clinical trials evaluating potential therapies, including remdesivir and chloroquine, are being conducted. Lopinavir and ritonavir are limited in transplantation due to drug-drug interactions with calcineurin inhibitors [2], and also have been found useless according to a recent study [3]. To the best of our knowledge, reported case of transplant recipient with COVID-19 is rare [4]. Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive therapy on COVID-19 infection are lacking. We report two cases of COVID-19 in renal transplant recipients
Data Loading...
