Different patterns of myocardial iron overload by T2* Cardiovascular MR as markers of risk for cardiac complication in t
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MODERATED POSTER PRESENTATION
Open Access
Different patterns of myocardial iron overload by T2* Cardiovascular MR as markers of risk for cardiac complication in thalassemia major Antonella Meloni1*, Vincenzo Positano1, Petra Keilberg1, Brunella Favilli1, Claudio Ascioti2, Gianluca Valeri3, Angelo Zuccarelli4, Anna Pietrapertosa5, Massimo Lombardi1, Alessia Pepe1 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background Cardiac complications mainly related to myocardial iron overload (MIO) remain the main cause of morbidity and mortality in thalassemia major (TM). Thalassemia cardiomyopathy is treatable and partly reversible if appropriate chelation therapy is instituted in time. The validated multislice multiecho T2* Cardiovascular Magnetic Resonance (CMR) technique has permitted to quantify segmental and global myocardial iron burden detecting different patterns of iron overload. Aim of our study was to verify the risk of cardiac complications related to different patterns of MIO in a large cohort of TM patients. Methods We considered 812 TM patients for who CMR and cardiac data were collected in a central data base. Three short-axis views (basal, medium, apical) of the left ventricle were acquired using a multislice multiecho T2* sequence. Using a previously validated software the 16 segmental T2* values and the mean global heart T2* value were provided. A conservative cut off of 20 ms was considered the limit of normal for the segmental and global T2* values.
heterogeneous MIO and global heart T2*≥20 ms; group IV (42%) with no MIO (all segments with T2*≥20 ms). The percentage of patients with cardiac complications was significantly different in the 4 groups (group I 24.6%, group II 20.6%, group III 8.4%; group IV 16.4%; P
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