Distribution and effect of ghrelin genotype on plasma lipid and apolipoprotein profiles in obese and nonobese Chinese su
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ORIGINAL ARTICLE
Distribution and effect of ghrelin genotype on plasma lipid and apolipoprotein profiles in obese and nonobese Chinese subjects Ruqiang Bai 1 & Yu Liu 2 & Chong Zhao 3 & Jinhang Gao 3 & Rui Liu 3 Received: 23 June 2020 / Accepted: 4 November 2020 # Hellenic Endocrine Society 2020
Abstract Purpose The hormone ghrelin has an important role in a wide range of metabolic and nonmetabolic processes. Ghrelin gene polymorphisms have been reported to influence obesity or lipid abnormalities in some ethnic groups. This study was conducted mainly to examine the possible association of ghrelin − 604 G > A and Leu72Met polymorphisms with obesity and related traits in a Southwest Chinese population. Methods Three hundred and eighty-six Han Chinese individuals (118 obese and 268 normal weight control subjects) in the Chengdu area were studied using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Clinical and biochemical parameters were also analyzed. Results The genotype and allele frequencies of ghrelin gene polymorphisms in participants with obesity showed no significant difference compared to those in nonobese controls. However, in the nonobese control group, carriers of genotype Met/Met at the Leu72Met site had higher serum TC and LDL-C concentrations than those of the Leu/Leu genotype (P < 0.05). When nonobese subjects were stratified by sex, the genotype-dependent effects on TC and LDL-C were more evident, although this was observed only in females. In addition, genotype-related effects on these lipid parameters at this site were observed in male obese subjects only. Conclusions The Leu72Met polymorphism of the ghrelin gene is associated with altered plasma TC and LDL-C concentrations, and the effects on TC and LDL-C levels are sex-dependent in both nonobese and obese subjects in the Chinese population of the Chengdu area. Keywords Overweight/obese . Ghrelin . Gene polymorphism . PCR-RFLP . Genotype
Introduction Obesity, a critical chronic disorder, is strongly associated with an adverse profile of dyslipidemia and increased health risks, including diabetes, elevated blood pressure, and coronary artery disease [1, 2]. The prevalence of obesity is increasing in both developed countries [3] and developing countries, including China, a country with a population of 1.4 billion
* Rui Liu [email protected] 1
Department of Stomatology, West China College of Stomatology, Sichuan University, Chengdu, China
2
Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
3
Laboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China
people [4, 5]. Therefore, obesity remains a major public health concern worldwide. The causes of obesity have not as yet been fully determined. However, it is widely accepted that environmental factors in combination with genetic factors may be major contributors to this condition [6, 7]. It is well established that environme
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