Ghrelin and Apolipoprotein AIV Levels Show Opposite Trends to Leptin Levels During Weight Loss in Morbidly Obese Patient
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RESEARCH ARTICLE
Ghrelin and Apolipoprotein AIV Levels Show Opposite Trends to Leptin Levels During Weight Loss in Morbidly Obese Patients E. Pardina & M. D. López-Tejero & R. Llamas & R. Catalán & R. Galard & H. Allende & V. Vargas & A. Lecube & J. M. Fort & J. A. Baena-Fustegueras & J. Peinado-Onsurbe
Received: 18 July 2008 / Accepted: 2 December 2008 / Published online: 27 January 2009 # Springer Science + Business Media, LLC 2009
Abstract Background Although bariatric surgery is the most common procedure used to induce weight loss in morbidly obese patients, its effect on plasma satiety factors (leptin, ghrelin, and apolipoprotein (apo)-AIV) is controversial. E. Pardina : M. D. López-Tejero : R. Llamas : J. Peinado-Onsurbe (*) Dept. Bioquímica y Biología Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal, 645, 08028 Barcelona, Spain e-mail: [email protected] R. Catalán : R. Galard Biochemistry Department, Hospital Universitari Vall D’hebron, Institut De Recerca Vall D’hebron, Universitat Autónoma De Barcelona, Barcelona, Spain H. Allende : V. Vargas CIBER de Enfermedades Hepáticas y Digestivas (CIBERHD), Instituto de Salud Carlos III (ISCIII), Institut de Recerca Vall D’Hebron, Universitat Autónoma De Barcelona, Barcelona, Spain A. Lecube CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Diabetes Research Unit, Hospital Universitari Vall D’hebron, Institut De Recerca Vall D’hebron, Universitat Autónoma De Barcelona, Barcelona, Spain J. M. Fort : J. A. Baena-Fustegueras Endocrinology Surgery Unit, Hospital Universitari Vall D’hebron, Institut De Recerca Vall D’hebron, Universitat Autónoma De Barcelona, Barcelona, Spain
The aim of this work was to analyze these parameters before and at different times after surgery. Methods Plasma was obtained from 34 patients before undergoing Roux-en-Y gastric bypass and during weight loss in the 12 months following surgery. Results Morbidly obese patients had significantly higher values (147%) of leptin than normal-weight (NW) persons, while their ghrelin levels were 46% less than NW. Apo-AIV levels had approximately the same value in both groups (obese and NW). During weight loss, leptin decreased by 75% and ghrelin increased by 78%. Both parameters reached values less than or near NW, respectively, at 1 year after surgery. During the first month after surgery, apo-AIV plasma levels decreased (47%) but later increased and finally returned to preoperative values. Apo-AIV levels were correlated negatively with leptin and positively with ghrelin. High-density lipoprotein (HDL) levels were positively correlated with those of ghrelin and apo-AIV. Conclusions During weight loss, plasma leptin and ghrelin could be good markers of total fat decrease. Ghrelin could also indicate gastric mucous improvement, whereas apo-AIV could indicate the recovery of intestinal function. Changes produced in the HDL levels of morbidly obese patients during weight loss suggest a decreased risk of coronary disease. Keywords Baria
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