DNA Replication, Recombination, and Repair Molecular Mechanisms and

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their bio

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A Replication, Recombination, and Repair Molecular Mechanisms and Pathology

DNA Replication, Recombination, and Repair

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Fumio Hanaoka • Kaoru Sugasawa Editors

DNA Replication, Recombination, and Repair Molecular Mechanisms and Pathology

Editors Fumio Hanaoka Department of Life Science Faculty of Science Gakushuin University Tokyo Japan

Kaoru Sugasawa Biosignal Research Center Organization of Advanced Science and Technology Kobe University Kobe Japan

ISBN 978-4-431-55871-2 ISBN 978-4-431-55873-6 DOI 10.1007/978-4-431-55873-6

(eBook)

Library of Congress Control Number: 2015958719 Springer Tokyo Heidelberg New York Dordrecht London © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Japan KK is part of Springer Science+Business Media (www.springer.com)

Preface

Replication, recombination, and repair of DNA are fundamental molecular mechanisms for organisms to maintain (and sometimes intentionally alter) genetic information. Although these processes, individually, have been important subjects of molecular biology since its emergence, we have recently become aware that they are actually much more intimately related to one another than we used to realize. Furthermore, the research fields of DNA replication, recombination, and repair have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other pivotal processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation of gene expression, and so on. Most importantly, now we know that DNA replication, recombination, repair, and related functions form a sophisticated network in order to maintain, regulate, and even evolve genetic information. Since quite some time ago, perturbation of normal DNA replication, recombination, or the repair process has been implicated in carcinogenesis, mainly through inducing genome instability. However, recent