DNA Repair Methods and Protocols
The volume outlines techniques used to study the primary mechanisms of important DNA repair pathways. The chapters in this book are organized into five sections, each discussing a specific aspect of repair biology. Part I reviews the role of post-translat
- PDF / 10,575,106 Bytes
- 347 Pages / 504.63 x 737.01 pts Page_size
- 90 Downloads / 228 Views
Lata Balakrishnan Jason A. Stewart Editors
DNA Repair Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
DNA Repair Methods and Protocols
Edited by
Lata Balakrishnan Indiana University – Purdue University, Indianapolis, IN, USA
Jason A. Stewart Department of Biological Sciences, University of South Carolina, Columbia, SC, USA
Editors Lata Balakrishnan Indiana University – Purdue University Indianapolis, IN, USA
Jason A. Stewart Department of Biological Sciences University of South Carolina Columbia, SC, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9499-1 ISBN 978-1-4939-9500-4 (eBook) https://doi.org/10.1007/978-1-4939-9500-4 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Maintenance of genome integrity is important for all aspects of cellular physiology and development. Alterations in our genome due to endogenous and exogenous factors threaten the integrity of our genome and therein have a direct consequence to human health. Evolution of DNA repair mechanisms has ensured that the majority of the DNA damage acquired is often quickly and efficiently reversed to restore genome stability. Based on the type of damage encountered, different repair proteins are mobilized to the site of damage for DNA repair. Over the past five decades, our understanding of these repair pathways has increased by convergent knowledge from chemists, biochemists
Data Loading...
