Do high blood glucose peaks contribute to higher HbA 1c ? Results from repeated continuous glucose measurements in child
- PDF / 278,681 Bytes
- 7 Pages / 595.22 x 842 pts (A4) Page_size
- 90 Downloads / 190 Views
Do high blood glucose peaks contribute to higher HbA1c? Results from repeated continuous glucose measurements in children Samuelsson Ulf, Hanas Ragnar, Whiss Per Arne, Ludvigsson Johnny Linköping, Sweden
Methods: Thirty-two patients were randomized into two study arms, one open and the other blinded. Both arms had 8 pump users and 8 patients with multiple daily injections (MDI). After three months the two arms crossed over. Both study arms wore a continuous glucose monitoring system (CGMS) for 3 days every 2 weeks. HbA1c was determined before and after each 3-month study period. Results: There was no relationship between HbA1c and s.c. glucose AUC or between HbA1c and the number of peaks >15.0 mmol/L when all CGMS profiles during the 6 months were taken together. Children on MDI showed a positive relationship between HbA1c and AUC (P15.0 mmol/L (r=0.04). This lack of relationship was also seen when comparing the HbA1c values with three different baselines of AUC (10, 15 and 20 mmol/L). When the low HbA1c values (
Data Loading...
