Dosimetric evaluation with knowledge-based planning created at different periods in volumetric-modulated arc therapy for
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Dosimetric evaluation with knowledge‑based planning created at different periods in volumetric‑modulated arc therapy for prostate cancer: a multi‑institution study Hajime Monzen1 · Mikoto Tamura1 · Yoshihiro Ueda2 · Jun‑ichi Fukunaga3 · Tatsuya Kamima4 · Yuta Muraki5 · Kazuki Kubo1 · Kiyoshi Nakamatsu6 Received: 31 March 2020 / Revised: 16 September 2020 / Accepted: 16 September 2020 © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2020
Abstract Dosimetric evaluation and variation assessment were performed with two knowledge-based planning (KBP) models created at different periods for volumetric-modulated arc therapy (VMAT) for prostate cancer at five institutes. The first and second models (F- and S-models) for KBP were created before April 2017 and April 2019, respectively. The S-model was created using feedback plans from the F-model. Dose evaluation was compared between the two models using the same two computed tomography (CT) datasets and structures. The evaluation metrics were the dose received by 95.0% and 2.0% of the planning target volume (PTV); dose–volume parameters to the rectum and bladder as V90, V80, and V50; and monitor unit (MU). Dosimetric variation was compared by exporting estimated dose–volume histograms for each model to the Model Analytics website and assessing the organ at risk volume. There were no dosimetric differences between the two models for PTV. The V50 of the rectum in the S-model had improved compared to that of the F-model (case I: 49.3 ± 15.6 and 43.5 ± 15.2 [p = 0.08]; case II: 42.5 ± 16.9 and 36.0 ± 15.6 [p = 0.138]). The differences in other parameters were within ± 1.8% between the rectum and the bladder. The MU was slightly higher in the S-model than in the F-model, and dosimetric variation was reduced to the rectum and bladder among all the institutes. The polished S-model for KBP could be used for standardization of the plan quality and sharing of KBP models in VMAT for prostate cancer. Keywords Rapidplan · Knowledge-based planning · Volumetric-modulated arc therapy · Prostate · Plan quality · Standardization
1 Introduction Plan quality variability in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT), which use inverse planning, depends on planners’ and institutional experiences; the complexity of IMRT/VMAT goals; * Hajime Monzen [email protected] 1
Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, 377‑2 Ohnohigashi, Osakasayama, Osaka 589‑8511, Japan
2
Department of Radiation Oncology, Osaka International Cancer Institute, 3‑1‑69 Otemae, Chuo‑ku, Osaka 537‑8567, Japan
3
Divisin of Radiology, Department of Medical Technology, Kyushu University Hospital, 3‑1‑1 Maidashi, Higashi‑ku, Fukuoka 812‑8582, Japan
and differences in patient anatomy. It can compromise the gains of high-precision radiotherapy [1–3]. A commercial tool called RapidPlan (RP) is a supervised machine learning approach integrated in the Eclipse treatment planning system (TPS) (Vari
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