Double crosslinking hydrogel with tunable properties for potential biomedical application
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ORIGINAL PAPER
Double crosslinking hydrogel with tunable properties for potential biomedical application Zhi Li 1,2 & Li Chen 2 & Mengting Xu 2 & Yan Ma 2 & Lei Chen 3 & Fangyin Dai 1,2,3
# The Polymer Society, Taipei 2020
Abstract Weak performance of hydrogel fabricated by a sole component limits their applications. In this study, we proposed a facile preparation of hydrogels by using three natural polymers, carboxymethyl chitosan, alginate and agarose. The fabricated carboxymethyl chitosan/sodium alginate/agarose hydrogels were further treated by divalent calcium ions to form a double crosslinked network inside. These double crosslinked hydrogels showed tunable mechanical property and the compressive strength ranged from 176 Pa to 685 Pa by varying the crosslinking degree. They also exhibited excellent swelling behavior (more than 1500%), good degradability and good biocompatibility, indicating their potential for application in wound healing, drug delivery and bone tissue engineering. Keywords Hydrogel . Agarose . Biomedical application
Introduction Hydrogels possess crosslinked networks dispersing in an aqueous microenvironment. With diversified physical, chemical and biological properties, hydrogels are widely used in fields of drug delivery [1, 2], wound healing [3], tissue engineering [4], actuators [5], sensors [6], and electronics [7]. It is evident that the properties of hydrogels are closely related to their cross-linking mechanisms which involves thermal condensation, self-assembly, ionic gelation, electrostatic interaction, and chemical cross linking [8, 9]. In addition, the polymeric materials for fabricating hydrogels can also affects the characteristics as well as their applications.
Zhi Li, Li Chen and Fangyin Dai contributed equally to this work. * Fangyin Dai [email protected] 1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China
2
Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, College of Textile and Garment, Southwest University, Chongqing 400715, China
3
Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Biotechnology, Southwest University, Chongqing 400715, China
Natural polymers and their derivatives, such as gelatin, alginate, cellulose, chitin and chitosan (CS) and so on, have a wide range of sources as well as features of non-toxicity, biocompatibility and biodegradability so that they are widely adopted in fabricating hydrogels. CS, produced by deacetylation of chitin, is a derivative of chitin. For purpose of antibacterial activity, CS is capable of interfering with the charge distribution on the cell wall and cell membrane, penetrating the cell wall and cell membrane in the form of small molecules and then binding the bacterial DNA to block DNA and RNA synthesis, and/or combining the metal elements or trace elements necessary for the bacterial growth [10, 11]. Moreover, antifungal property, anti-tumor activity, hemostatic function, and especially acceleratin
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