Doxorubicin
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Ischaemic gastroduodenal ulcer: case report A 71-year-old man developed ischaemic gastroduodenal ulcer following administration of doxorubicin for multinodular hepatocarcinoma. The man, who had liver cirrhosis and multinodular hepatocarcinoma secondary to hepatitis C virus (HCV), was admitted for hepatic transarterial chemoembolisation (TACE) using doxorubicin. Using a right femoral access with supraselective catheterisation of a hepatic branch, 200 micron particles were administered preloaded with a total of 45mg of doxorubicin. The procedure was performed without incident. A few hours after completion of TACE, he had persistent vomiting and severe epigastralgia. Therefore, an urgent gastroscopy was performed. The endoscopy revealed a large ulcerated and irregular area affecting the anterior surface of the antrum, the pylorus and part of the duodenal bulb. The ulcer was fibrin coated and had areas of erythematous mucosa and raised margins. This injury was suggestive of ischaemic gastroduodenal ulcer secondary to TACE with doxorubicin. The ischaemic gastroduodenal ulcer was treated conservatively with gut rest, serum therapy and omeprazole. A repeat gastroscopy 1 month later showed that the previous large ulcer had disappeared, but there was a slightly nodular mucosal appearance on the anterior surface of the antrum. de Zarraga Mata C, et al. Ischemic gastroduodenal ulcer as a complication of hepatic hepatocarcinoma transarterial chemoembolization. Revista de Gastroenterologia del Peru 803504103 39: 367-369, No. 4, 2019. Available from: URL: https://pubmed.ncbi.nlm.nih.gov/32097399/ [Spanish; summarised from a translation]
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Reactions 3 Oct 2020 No. 1824
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