Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA
The variety of viewpoints expressed in this book illustrate the many contro versies surrounding MDMA [1]. On the one hand, the proponents ofMDMA use believe this agent offers a unique psychoactive effect that may have important clinical applications, esp
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ECSTASY: THE CLINICAL, PHARMACOLOGICAL AND NEUROTOXICOLOGICAL EFFECTS OF THE DRUGMDMA
Edited by STEPHEN J. PEROUTKA Stanford University Medical Center
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KLUWER ACADEMIC PUBLISHERS BOSTON IDORDRECHT ILONDON
Distributors for North America: Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, MA, 02061, USA for all other countries: Kluwer Academic Publishers Group, Distribution Centre, Post Office Box 322, 3300 AH Dordrecht, The Netherlands
Library of Congress Cataloging-in-Publication Data Ecstasy: the clinical, pharmacological, and neurotoxicological effects of the drug MDMA / edited by Stephen]. Peroutka. p. cm. - (Topics in the neurosciences; TNSC9) Includes bibliographies and index. ISBN- 13:978- I -4612-8799-5 DOl: 10.1007/978-1-4613-1485-1
e-ISBN-13:978- I -4613-1485-1
1. MDMA (Drug) 2. Central nervous system-Effect of drugs on. I. Peroutka, Stephen]. II. Series. [DNLM: 1. Ampheamines-analogs & derivatives. 2. Amphetamines-pharmacology. 3. Nervous System-drug effects. WI T054VF v. 9/ QV 102 E19] RM666.M35E371989 615' .785-dc 20 DNLMIDLC for Library of Congress
Copyright
© 1990 by Kluwer Academic Publishers Softcover reprint of the hardcover I st edition 1990 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, MA 02061.
CONTENTS
List of Contributors
Vll
Preface
Xl
1. History ofMDMA ALEXANDER T. SHULGIN
2. The Therapeutic Use of MDMA GEORGE R. GREER and REQUA TOLBERT
21
3. Testing Psychotherapies and Drug Therapies: The Case of Psychedelic Drugs JAMES B. BAKALAR and LESTER GRINSPOON
37
4. Recreational Use ofMDMA
53
STEPHEN J. PEROUTKA
5. Human Deaths and Toxic Reactions Attributed to MDMA and MDEA
63
GRAEME P. DOWLING
6. The Public Health Implications ofMDMA Use
77
JEROME BECK
7. Structure-Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Agents? DAVID E. NICHOLS and ROBERT OBERLENDER
105
8. Neurochemical Effects ofMDMA
133
JAMES W. GlBB, DONNA STONE, MICHEL JOHNSON,
and
GLEN R. HANSON
V
vi Contents
9.
