Effect of an organotin catalyst on the physicochemical properties and biocompatibility of castor oil-based polyurethane/
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ARTICLE Effect of an organotin catalyst on the physicochemical properties and biocompatibility of castor oil-based polyurethane/cellulose composites Santiago Villegas-Villalobos Master in Process Design and Management, Research Group on Energy, Materials and Environment, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia
Luis E. Díaz Bioprospecting Research Group, Universidad de La Sabana, Chía 140013, Colombia
Guillermo Vilariño-Feltrer Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia 46022, Spain
Ana Vallés-Lluch and José A. Gómez-Tejedor Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia 46022, Spain; and Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valencia 46022, Spain
Manuel F. Valeroa) Research Group on Energy, Materials and Environment, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia (Received 30 April 2018; accepted 23 July 2018)
Polyurethane/cellulose composites were synthesized from castor-oil-derived polyols and isophorone diisocyanate using dibutyltin dilaurate (DBTDL) as the catalyst. Materials were obtained by adding 2% cellulose in the form of either microcrystals (20 lm) or nanocrystals obtained by acid hydrolysis. The aim was to assess the effects of filler particle size and the use of a catalyst on the physicochemical properties and biological response of these composites. The addition of the catalyst was found to be essential to prevent filler aggregations and to enhance the tensile strength and elongation at break. The cellulose particle size influenced the composite properties, as its nanocrystals heighten hydrogen bond interactions between the filler surface and polyurethane domains, improving resistance to hydrolytic degradation. All hybrids retained cell viability, and the addition of DBTDL did not impair their biocompatibility. The samples were prone to calcification, which suggests that they could find application in the development of bioactive materials.
I. INTRODUCTION
Various types of diseases and injuries can lead to tissue damage, loss of organ function, fractures, and disfigurations. The treatment for these types of problems demands biomaterials that promote recovery of proper function in various regions of the body. The use of polyurethanes as biomaterials has increased due to their excellent mechanical properties and biocompatibility.1 For this reason, multiple biomedical devices are designed starting from polyurethanes of various origins according to the requirements of each application.2 Nevertheless, biomaterials that combine the properties of polyurethanes with new features deserve more attention, as these materials could further enable the treatment of different physical disorders.3 In recent years, the incorporation of fillers into polymeric matrices has been explored, and the results a)
Address all correspondence to this author. e-mail: [email protected] DOI: 10.1557/jmr.2018.286
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