Hepatoprotective effects of Meconopsis aculeata extract against CCl 4 induced oxidative damage in rats
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RESEARCH ARTICLE
Hepatoprotective effects of Meconopsis aculeata extract against CCl4 induced oxidative damage in rats Sumaya Hassan1 · Muzaffar Ahmad Bhat1 · Nasreena Sajjad1 · Rohaya Ali1 · Showkat Ahmad Ganie2 · Rabia Hamid1,3 Received: 20 November 2018 / Accepted: 27 July 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract The objective of the present study was to investigate the hepatoprotective effects of methanol extract of Meconopsis aculeata, an important medicinal plant of Kashmir Himalayas, against CCl4 induced oxidative damage in rats. Acute hepatotoxicity was induced in Wistar albino rats by single intraperitoneal injection of C Cl4 at 1 ml/kg body weight dose. Methanol extract of M. aculeata was orally administered at the doses of 100, 200 and 300 mg/kg body weight/day for 14 days. The results revealed that administration of C Cl4 caused a significant increase in serum AST, ALT and LDH levels as compared to the control group (p
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