Effect of proton pump inhibitors on Rubidium-82 gastric uptake using positron emission tomography myocardial perfusion i
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Department of Medicine (Cardiology), University of Ottawa Heart Institute, Ottawa, ON, Canada b King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia c Department of Epidemiology, University of Ottawa, Ottawa, Canada d Department of Radiology, University of Ottawa, Ottawa, Canada Received Feb 20, 2019; accepted Jul 24, 2019; accepted Aug 17, 2019 doi:10.1007/s12350-019-01954-y
Background. Rb-82 positron emission tomography (PET) myocardial perfusion imaging (MPI) is a robust tool for the evaluation of coronary artery disease (CAD). However, gastric uptake and spillover can be seen in 10% of Rb-82 PET MPI studies, commonly affecting the inferior wall, and can preclude the accurate identification of myocardial ischemia. We sought to understand the relationship between Rb-82 gastric uptake and the use of proton pump inhibitors (PPI). Methods. 600 consecutive patients who presented for a clinically indicated Rb-82 PET MPI study were prospectively enrolled. In addition to the clinical history, PPI use was ascertained (medication, dose, frequency and duration of use, and time of last dose). Patients were categorized as PPI and non-PPI users. Rb-82 uptake in the gastrium, myocardium, and liver were measured at rest. Absolute uptake values and gastric:hepatic ratios were compared in PPI and non-PPI users. Result. Of 600 enrolled patients, 181 (30.2%) patients were using PPI. The gastric Rb-82 uptake in PPI users was 23% higher than non-PPI users (146 ± 52 kBq/cc vs 119 ± 40 kBq/cc, respectively; P < 0.001). The resting gastric:hepatic Rb-82 uptake ratio was also 23% higher in PPI vs non-PPI users (2.7 ± 1.0 vs 2.2 ± 0.8, respectively; P < 0.001). Conclusion. The gastric uptake of Rb-82 appears to be greater in patients actively using PPI and may identify a group who might be at greater risk of non-diagnostic Rb-82 PET MPI. (J Nucl Cardiol 2019)
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12350-019-01954-y) contains supplementary material, which is available to authorized users. The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarizes the contents of the paper and is free for reuse at meetings and presentations. Search for the article DOI on SpringerLink.com. The authors have also provided an audio summary of the article, which is available to download as ESM, or to listen to via the JNC/ASNC Podcast.
Reprint requests: Benjamin J. W. Chow, MD, FRCPC, FACC, FESC, FASNC, FSCCT, Department of Medicine (Cardiology), University of Ottawa Heart Institute, Ottawa, ON, Canada; [email protected] 1071-3581/$34.00 Copyright © 2019 American Society of Nuclear Cardiology.
Alzahrani et al. Effect of proton pump inhibitors on Rubidium-82 gastric uptake
Journal of Nuclear CardiologyÒ
Spanish Abstract Antecedentes. la imagen de perfusión cardiaca con tomografía por emisión de positrones (PET) usando Rb-82, es una herramienta sólida en la evaluación de la enfermedad arterial coronaria (CAD). Sin emba
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