Effect of short-term intermittent exposure to waterborne estradiol on the reproductive physiology of the round goby ( Ne
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RESEARCH ARTICLE
Effect of short-term intermittent exposure to waterborne estradiol on the reproductive physiology of the round goby (Neogobius melanostomus) Tatiana Guellard 1
&
Hanna Kalamarz-Kubiak 1 & Bartłomiej Arciszewski 2
Received: 23 October 2019 / Accepted: 11 June 2020 # The Author(s) 2020
Abstract The objective of this study was to determine how the short-term exposure to a supraphysiological concentration of waterborne 17β-estradiol (E2) influences on melatonin (Mel) and thyroxine (T4) concentrations in plasma and E2 and 11-ketotestosterone (11-KT) concentrations in plasma and gonads in both sexes of round goby (Neogobius melanostomus) during the pre-spawning, spawning, late spawning and non-spawning phases. The experimental protocol was based on short-term, repeated exposures of fish to a supraphysiological dose of waterborne E2. Mel level was unchanged on exposure to E2 during the investigated phases, and its role in determining a time frame for spawning in both sexes of round goby seems to be stable in those conditions. T4 and sex steroids (E2 and 11-KT) were sensitive to the exposure of E2, and those changes influence gonads by accelerating oocyte development, ovulation and regression and inhibiting spermatogenesis in this species. The results demonstrate that the physiological responses of fish in all investigated phases were altered over a short window of exposure, indicating that short-term exposure to a supraphysiological dose of E2 may impact fish in the wild. Furthermore, round goby can be recommended as a very suitable model for studying endocrine disruptors, which is sensitive to even short exposure to E2. Keywords Fish . Endocrine disruptions . 17β-estradiol . Melatonin . Thyroxine . Sex steroids . Reproductive cycle . Neogobius melanostomus
Introduction There are several compounds entering an aquatic environment with municipal, pharmaceutical, agricultural and industrial sewage that can disturb the functioning of the endocrine system in fishes. These types of compounds belong to pollutants called endocrine disrupting compounds (EDCs). EDCs have Responsible Editor: Philippe Garrigues Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11356-020-09702-3) contains supplementary material, which is available to authorized users. * Tatiana Guellard [email protected] 1
Genetics and Marine Biotechnology Department, Institute of Oceanology, Polish Academy of Sciences, Sopot, Poland
2
Prof. Krzysztof Skóra Hel Marine Station, Institute of Oceanography, Faculty of Oceanography and Geography University of Gdańsk, Hel, Poland
been defined as an exogenous substance or mixture of substances that change functions of the endocrine system and provoke adverse effects in an intact organism, its offspring and also subpopulations (Vos et al. 2000). EDCs mimic endogenous hormones and this way stimulate, block or disrupt their synthesis and metabolism leading to adverse developmental, reproductive, behavioural, neurological or immune effects in organisms
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