Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder
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ORIGINAL ARTICLE
Effect of vitamin D treatment in children with attention‑deficit hyperactivity disorder Nadia Dehbokri1,5 · Gholamreza Noorazar2 · Aida Ghaffari3 · Gita Mehdizadeh1,5 · Parvin Sarbakhsh4 · Saba Ghaffary5 Received: 19 May 2018 / Accepted: 9 November 2018 © Children’s Hospital, Zhejiang University School of Medicine 2018
Abstract Background In this research the symptom improvement of attention-deficit hyperactivity disorder (ADHD) of children was assessed by oral vitamin D administration in Tabriz, Iran. Methods In this double-blind, randomized clinical trials, 96 children (2–18 years) were enrolled to placebo and vitamin D groups. Children took vitamin D pearl (50,000 IU/week) or placebo for 6 weeks. Children, who had the change in methylphenidate dosage and received any anticonvulsants and corticosteroids were excluded from the research. ADHD symptoms were diagnosed by Conners parent rating scale (CPRS) test at baseline and after intervention. ADHD Conners divided into inattention (IA), hyperactivity/impulsivity (H/I) and combination type (C) subscales. Vitamin D serum level was assessed at baseline and after 8 weeks in both groups. Results The differences between CPRS and its subscales were not significant at baseline (P > 0.05). The Conners IA score was decreased in vitamin D group (P
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