Effects of Enzymatic Hydrolysate of Oyster on Erectile Function in Male Hemicastrated Rats
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Effects of Enzymatic Hydrolysate of Oyster on Erectile Function in Male Hemicastrated Rats Hai‑Yan Wang1,2 · Zheng Yan2,4 · Shuang Liu2 · Ai‑Qing Liu3 · Jun‑She Sun1 Accepted: 28 November 2019 © Springer Nature B.V. 2019
Abstract Oysters have been thought to significantly improve the male sexual function for thousands of years. To explore the effects of an enzymatic hydrolysate of oyster preparation on erectile dysfunction (ED), hemicastrated male rats were divided into control, positive control and oyster hydrolysate high dose group (0.617 g/kg body weight per day), medium dose group (0.308 g/kg) and low dose group (0.103 g/kg), respectively. After castration, the growth, development and the organ indexes of accessory sex glands and immune organs of the rats were significantly decreased than those of normal rats. Oyster hydrolysate significantly shortens the latency of penile erection induced by electrical stimulation in a dose-dependent manner, indicating that oyster hydrolysate also has significant effects on alleviating ED. Further analysis revealed that the serum levels of testosterone and luteinizing hormone and NO were significantly higher than those in the castrated model group, and were similar to those in the normal control group, indicating that oyster hydrolysate promotes the synthesis of testosterone by stimulating the synthesis of luteinizing hormone, which then increased the serum NO content through the NO-cGMP signaling pathway. Keywords Bioactive peptide · Oyster hydrolysate · Erectile function · Testosterone · NO
Introduction Erectile dysfunction is the inability to obtain or maintain an erection firm enough to have satisfactory sexual intercourse (Rosen et al. 1997). Penile erection is one of the most important male sexual functions, which directly affects the quality of life of the male as well as the whole family. Normal psychological sexual arousal, physiological structure, endocrine, and nerve and vascular functions are the primary factors involved in penile erection, and abnormality in any of these factors will lead to erectile dysfunction (Shamloul et al. 2013). At present, the clinical treatment of ED is predominately oral medications. However, these medications * Jun‑She Sun [email protected] 1
Chinese Academy of Agricultural Engineering Planning & Design, Beijing 100125, China
2
Beijing Semnl Biotechnology Co., Ltd., Beijing 100062, China
3
Hainan Semnl Biotechnology Co., Ltd., Wenchang 571300, China
4
College of Bioengineering, Beijing Ρolytechnic, Beijing 100176, China
usually have adverse reactions, and are thus not suitable for long-term administration (Eardley et al. 2010). Research on safe and efficient foods or medications to alleviate and treat ED is an area of active research. Oysters belong to the family Ostreae, order Pterioida, class Bivalvia and phylum Mollusca, and are a type of marine shellfish with substantial edible and medicinal value (Wang et al. 2014). Oysters are believed to have significant effects on treating deficiencies and strengthening yang
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