Effects of High-Dose of Copper Amino Acid Complex on Laying Performance, Hematological and Biochemical Parameters, Organ
- PDF / 668,251 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 58 Downloads / 164 Views
Effects of High-Dose of Copper Amino Acid Complex on Laying Performance, Hematological and Biochemical Parameters, Organ Index, and Histopathology in Laying Hens Qin Zhou 1 & Jiaming Zhu 1 & Bing Liu 1 & Jialing Qiu 1 & Xintao Lu 1 & Brian Curtin 2 & Fei Ji 2 & Dongyou Yu 1 Received: 15 July 2020 / Accepted: 21 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocated to 5 groups (90 birds per group) with 6 replicates of 15 birds each. After a 2-week acclimation on a basal diet (analyzed copper content 8.63 mg/kg), the birds were fed diets supplemented with 0 (control), 15, 75, 150, and 300 mg Cu/kg as Cu-Lys-Glu for 10 weeks. Results showed that, compared with the control group, dietary supplementation with 15, 75, and 150 mg Cu/kg as Cu-Lys-Glu did not affect (P > 0.05) laying performance, whereas hens receiving with 300 mg Cu/kg significantly decreased (P < 0.001) the laying rate as compared with the control. No significant differences (P > 0.05) were observed among the hens receiving 0, 15, 75, and 150 mg Cu/kg as Cu-LysGlu in hematological and serum biochemical parameters, organ indexes, and histopathological changes. However, hens receiving 300 mg Cu/kg significantly increased (P < 0.05) the concentrations of mean corpuscular volume (MCV), albumin (ALB), total bilirubin (TBILI), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (UN), and creatinine (CRE), as well as caused severe microscopic histopathological changes in the liver and kidney. In conclusion, 150 mg Cu/kg as Cu-Lys-Glu is identified as no-side-effect supplementation level in laying hens after daily administration for 70 days. Keywords Copper amino acid complex . Laying hen . Laying performance . Blood parameter . Histopathology
Introduction Copper (Cu) has been proved as an essential trace element for animals. As a cofactor, Cu plays an indispensable role in maintaining the normal structure and function of a variety of enzymes, which are broadly involved in growth, development, and reproductive processes [1]. Cu is commonly added to poultry diets at pharmacological levels, defined as levels above the nutritional requirement, for its growth-promoting effects and other promising benefits [2]. For example, addition of Cu to the ration would stimulate erythropoiesis and the * Dongyou Yu [email protected] 1
Key Laboratory of Animal Nutrition and Feed in East China of Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
2
Zinpro Corporation, 10400 Viking Drive, Suite 240, Eden Prairie, MN 55344, USA
production of heme, and decrease blood plasma lipid concentration in poultry [3, 4]. Organic Cu (che
Data Loading...
