Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats
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ORIGINAL ARTICLE
Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats Yilin Guo,1,2 Yaoyao Du,2 Lu Xie,3 Yiqiong Pu,1 Jianlong Yuan,4 Zhicheng Wang,5,7 Tong Zhang ,1,2,7 and Bing Wang 2,6,7
Abstract— Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and antiinflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induced by pyloric ligation (PL) and acetic acid and evaluated the protective effects of paeonol and gastroretention tablets of paeonol (GRT-Ps; 24, 48, and 96 mg/kg) on GU in rats and the effect of paeonol (48 mg/kg) on the intestinal flora. In vivo experiments showed that paeonol or GRT-Ps remarkably reduced gastric mucosal damage in a dose-dependent manner in the different types of models and improved the superoxide dismutase (SOD) activity and the malondialdehyde (MDA) content. And in fact, the sustained-release effect of GRT-Ps is more conducive to the improvement of GU compared with the rapid clearance of free Yilin Guo and Yaoyao Du contributed equally to this work. 1
Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, Shanghai, 201203, China 2 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, Shanghai, 201203, China 3 Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 185 Puan Road, Huangpu District, Shanghai, 200021, China 4 Fujian Medical Products Administration, 156 Dongpu Road, Fuzhou, 350013, China 5 Department of Laboratory Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Xuhui District, Shanghai, 200040, China 6 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Pudong New District, Shanghai, 201203, China 7 To whom correspondence should be addressed to Zhicheng Wang at Department of Laboratory Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Xuhui District, Shanghai, 200040, China. E-mail: [email protected]; and to Tong Zhang at School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, Shanghai, 201203, China. E-mail: [email protected]; and ; [email protected]
0360-3997/20/0000-0001/0 # 2020 Springer Science+Business Media, LLC, part of Springer Nature
Guo, Du, Xie, Pu, Yuan, Wang, Zhang, and Wang drugs. In the PL-induced model, gastric secretion parameters, that is, pH and total acid, showed significant differences compared with the model group. In addition, paeonol treatment can improve the richness and diversity of the intestinal flora and increase the amount of beneficial bacteria, such as Lactobacillus. Paeonol and its stable sustainedrelease tablet GRT-Ps can promote ulcer healing by inhibiting oxidative stress and re
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