Effects of poly(para-dioxanone-co-L-lactide) on the in vitro hydrolytic degradation behaviors of poly(L-lactide)/poly(pa
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i Baia) Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China
Congming Tang Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, People’s Republic of China
Dongliang Chen and Chengdong Xiong Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China (Received 18 September 2014; accepted 21 January 2015)
Poly(L-lactide)/poly(para-dioxanone) (PLLA/PPDO) (85/15 w/w) blends with 0, 1, 3, and 5 wt% poly(para-dioxanone-co-L-lactide) (PDOLLA) as a compatibilizer were prepared by solution coprecipitation. The in vitro hydrolytic degradation (HD) of blend bars with different contents of PDOLLA was studied by immersing the bars in a phosphate buffer solution (PBS) at pH 7.49. To estimate the degradation of blend bars, the weight loss, water absorption, thermal properties, surface morphology, and mechanical properties of blend bars, as well as the pH value changes of the PBS, were studied for 8 wk of HD. By adding 1 and 3 wt% PDOLLA, the weight loss of PLLA/PPDO (85/15 w/w) blends increased from 6.4 to 6.8 and 7.4% after 8 wk of HD, 6.2 and 15.6% increment, respectively, while, the average tensile strength of PLLA/PPDO (85/15 w/w) blends for 2–8 wk of HD increased from 25.8 to 29.0 MPa and 31.0 MPa, 12.4 and 20.2% increment, respectively. Considering their good mechanical properties and HD rate, the PLLA/PPDO (85/15 w/w) blends with 1 and 3 wt% PDOLLA are potential to be used as a medical implant material.
I. INTRODUCTION
For the problem of the environment and the need of medial application, biodegradable polymers are extensively investigated.1,2 Aliphatic polyesters such as poly(L-lactide) (PLLA), poly(e-caprolactone) (PCL), poly(para-dioxanone) (PPDO), poly(glycolic acid) (PGA) as well as their copolymers are biodegradable and have attracted the attention of researchers. 3 Among aliphatic polyesters, PLLA has been studied most extensively because it is biodegradable, biocompatible, bioabsorbable, and renewable and has high tensile strength and modulus.1,4–6 However, PLLA is brittle with elongation at break (EAB) ,10%,7 which restricts its wide application in many fields.8
Contributing Editor: Tao Xie a) Address all correspondence to this author. e-mail: [email protected] DOI: 10.1557/jmr.2015.31 J. Mater. Res., 2015
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To toughen PLLA, many methods, including copolymerization, blending, plasticity, and filling modification, have been reported.9,10 Even though copolymerization of L-lactide and other monomers can tailor the mechanical properties of PLLA-based material, this method is complex and difficult to synthesize in mass production. For plasticity, the addition of plasticizers into PLLA can increase the breaking elongation, which is accompanied by decreased EAB and elastic moduli.11 However, the plasticizer in PLLA intends to migrate to the s
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