Effects of resveratrol on mitochondrial biogenesis and physiological diseases
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REVIEW
Effects of resveratrol on mitochondrial biogenesis and physiological diseases Angelo Uriho2 · Xue Tang1,2 · Guowei Le1,2 · Shaojun Yang2 · Yves Harimana1 · Steven Papy Ishimwe2 · Lu Yiping2 · Kai Zhang2 · Shuhua Ma2 · Bertrand Muhoza1,2 Received: 15 November 2019 / Accepted: 31 July 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract Plants produce a number of biological active substances with healthy benefits. Resveratrol (3,5,4′-trihydroxystilbene), a polyphenol produced by plants has been associated with many health beneficial properties, including its ability to induce mitochondrial biogenesis and fight against health problems such as obesity, inflammation, heart diseases, cancers among others. Mitochondrial dysfunction is recognized as central to the pathogenesis and development of many diseases. Thus the present review describes how resveratrol (RSV) may counteract physiological and age-related diseases/disorders through its effect on mitochondrial biogenesis and function. In addition, we discuss the chemistry, main sources, and the doses of RSV shown in previous studies to be efficient for the prevention and treatment of different diseases. Through its ability to improve mitochondrial dysfunction, RSV can be used in the prevention and/or treatment of human physiological diseases. However, more research for optimal dose in a human scale is still relevant. This review brings new hope to the therapy of physiological diseases as it will provide useful future perspectives for the planning of clinical studies on RSV and mitochondrial dysfunction-related diseases. Keywords Resveratrol · Mitochondrial biogenesis · Polyphenol · Antioxidant · Anti-inflammatory · Intracellular signalling
Introduction Mitochondria are organelles responsible for several vital functions in our cells. Except for red blood cells, each of our cells has between 200 and 2000 mitochondria, and they are responsible for producing about 90 percent of the energy we use to live and grow (Siekevitz 1957). When these important structures fail, our cells produce less energy, which can injure and even cause cell death. Chronic fatigue and low-energy symptoms of many diseases can be attributed to mitochondrial dysfunction. Mitochondrial biogenesis is an increase in the cell’s mitochondrial mass resulting from numerous interactions between information and constituents of nuclear origin, e1aborated by the cytoplasmic protein synthesis system, and components e1aborated within the * Xue Tang [email protected] 1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
2
mitochondria, by the intramitochondrial protein synthesis system (Fabian Sanchis-Gomar et al. 2014). RSV is a plant polyphenolic micro-constituent with numerous protective potentials. It decreases mitochondrial superoxide anion generation by stimulating mitochondria biogenesis (Zhang et al. 2017). It has been previ
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