Resveratrol: Effects on Lipids and Cardiovascular Risk
- PDF / 172,210 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 50 Downloads / 218 Views
LIPIDS (J ORDOVAS, SECTION EDITOR)
Resveratrol: Effects on Lipids and Cardiovascular Risk E. Paul Cherniack & Bruce R. Troen
Published online: 3 January 2013 # Springer Science+Business Media New York (outside the USA) 2012
Abstract For several decades, there has been increasing interest in the possible use of resveratrol as a preventative agent in cardiovascular disease. Resveratrol exerts numerous effects on adipocyte, hepatocyte, and endothelial cell development and function. Many investigations have demonstrated the ability of resveratrol to regulate the adipocyte lifecycle, lipid synthesis, and improve hepatic lipid metabolism. Resveratrol has numerous vascular protective effects on endothelial tissue, including its antiplatelet activity. Resveratrol also reduces intracellular oxidative stress. Animal models of obesity and cardiovascular diseases have yielded important contributions to our understanding of the effects of resveratrol on the vasculature and the risk for pathology. In limited human studies, resveratrol reduces the release of proinflammatory cytokines and improves systemic glucose and insulin regulation and decreases cellular oxidative stress. Therefore, resveratrol has significant potential as both a prophylactic and treatment agent. However additional studies are required to more completely characterize its impacts on human physiology and its benefits in the setting of disease. Keywords Resveratrol . Cardiovascular disease . Lipids . Adipocytes . Oxidative stress . Inflammation
consumption and better health, however this association has proved controversial [1, 2]. While some studies imply an inverse relationship between cardiovascular mortality and alcohol consumption, others have failed to identify such a relationship [2–4]. Moderate wine consumption is associated with a lower incidence of cardiovascular disease [1, 5]. This has been termed the “French Paradox”, in which the French experience relatively low cardiovascular mortality despite a high saturated fat intake, and this is thought to be related to the intake of red wine [6]. Although it may be imprecise to pinpoint a single foodstuff as responsible for modification of cardiovascular disease risk in a large population, wine contains many organic molecules with potential health benefits, and much interest has focused on wine polyphenols, particularly resveratrol. For several decades, there has been increasing interest in the possible use of resveratrol as a preventative agent in cardiovascular disease. Resveratrol, a plant polyphenol found in many species including grapes and other berries, can activate sirtuins (SIRTs) [7, 8]. It is not certain whether resveratrol directly activates SIRTs, or whether an intermediate molecule, such as nicotinamide or adenosine monophosphate-activated protein kinase, is involved [9–12].
Introduction Adipocytes and Lipids A number of epidemiologic studies have outlined a positive association between moderate alcoholic beverage E. P. Cherniack : B. R. Troen Division of Gerontology and Geriatric Medicine,
Data Loading...
