Effects of synbiotic consumption on lipid profile: a systematic review and meta-analysis of randomized controlled clinic
- PDF / 3,268,003 Bytes
- 18 Pages / 595.276 x 790.866 pts Page_size
- 35 Downloads / 204 Views
REVIEW
Effects of synbiotic consumption on lipid profile: a systematic review and meta‑analysis of randomized controlled clinical trials Amir Hadi1 · Ehsan Ghaedi2,3 · Saman Khalesi4 · Makan Pourmasoumi5 · Arman Arab6 Received: 15 November 2019 / Accepted: 1 April 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background and aims Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive. The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile. Methods A systematic literature search of online databases PubMed, Scopus, ISI Web of science, Cochrane’s library and Google Scholar was conducted up to January 2019. Randomized controlled trials (RCTs) investigating the effects of synbiotics on lipid profile in adults were included. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model. Results A total of 23 RCTs with 1338 participants were included. Synbiotic consumption resulted in a significant decrease in plasma concentrations of total cholesterol (WMD = − 10.17 mg/dL; 95% CI − 15.74 to − 4.60; p 8 weeks. Keywords Synbiotics · Lipid profile · Cholesterol · Triglyceride · Meta-analysis
Introduction
* Arman Arab [email protected] 1
Halal Research Center of IRI, FDA, Tehran, Iran
2
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
3
Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
4
Physical Activity Research Group, Appleton Institute and School of Health Medical and Applied Sciences, Central Queensland University, Brisbane, Australia
5
Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran
6
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Cardiovascular disease (CVD) is a multifactorial disorder with a high mortality rate. It has been expected that by 2030, CVD will remain the leading causes of death affecting approximately 23.3 millions of people worldwide [1]. Dyslipidemia, defined by the presence of one or more abnormal serum lipid concentrations [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], is one of the main risk factors of CVD [2]. Therefore, the prevention and management of dyslipidemia have gained increasing attention over the past decades. Currently, various treatment options that target each aspect of the dyslipidemia pathogenesis have been explored and advocated, but recent guidelines encourage combination therapy for the management of multiple lipid abnormalities [3–5]. As a result, many dietary constituents and supplements are proposed to benefit lipid profile and c
Data Loading...
