The effectiveness of Baduanjin exercise for hypertension: a systematic review and meta-analysis of randomized controlled
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(2020) 20:304
BMC Complementary Medicine and Therapies
RESEARCH ARTICLE
Open Access
The effectiveness of Baduanjin exercise for hypertension: a systematic review and meta-analysis of randomized controlled trials Bao-yi Shao1, Xia-tian Zhang2, Robin W. M. Vernooij3,4, Qiu-yi Lv5, Yao-yang Hou5, Qi Bao6, Li-xing Lao7, Jian-ping Liu8, Ying Zhang8* and Gordon H. Guyatt9*
Abstract Background: Hypertension, a major risk factor of cardiovascular mortality, is a critical issue for public health. Although Baduanjin (Eight Brocades, EB), a traditional Chinese exercise, might influence blood pressure, glucose, and lipid status, the magnitude of true effects and subgroup differences remains unclear. Therefore, we performed a systematic review of relevant randomized controlled trials (RCTs) to evaluate the effect of EB on patient-important outcomes. Methods: We systematically searched PubMed, the Cochrane Library, Web of Science, and Chinese databases since inception until March 30, 2020. Meta-analysis was carried out using “meta” package in R 3.4.3 software. A prespecified subgroup analysis was done according to the type of comparisons between groups, and the credibility of significant subgroup effects (P < 0.05) were accessed using a five-criteria list. A GRADE evidence profile was constructed to illustrate the certainty of evidence. Results: Our meta-analysis, including 14 eligible trials with 1058 patients, showed that compared with routine treatment or health education as control groups, the mean difference (MD) in systolic blood pressure (SBP) of the EB groups was − 8.52 mmHg (95%CI:[− 10.65, − 6.40], P < 0.01) and diastolic blood pressure (DBP) was − 4.65 mmHg (95%CI: [− 6.55, − 2.74], P < 0.01). For blood pressure, the evidence was, however, of low certainty because of risk of bias and inconsistency, and for the outcomes of most interest to patients (cardiovascular morbidity and mortality directly), of very low certainty (measurement of surrogate only). Subgroup analysis showed there was no significant interaction effect between different type of comparisons (SBP P = 0.15; DBP P = 0.37), so it could be easily attributed to chance. Conclusion: Regularly EB exercising may be helpful to control blood pressure, but the evidence is only low certainty for blood pressure and very low certainty for cardiovascular morbidity and mortality. Rigorously designed RCTs that carry out longer follow-up and address patient-important outcomes remain warranted. Trial registration: PROSPERO Registration number: CRD42018095854. Keywords: Baduanjin, Hypertension, Systematic review, Meta-analysis, Randomized controlled trials
* Correspondence: [email protected]; [email protected] 8 Center for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China 9 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Att
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