Effects of topical administration of tafluprost and combination of tafluprost and timolol or tafluprost and betaxolol on
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ORIGINAL PAPER
Effects of topical administration of tafluprost and combination of tafluprost and timolol or tafluprost and betaxolol on Schirmer tear test, intraocular pressure, and pupil size in clinically healthy dogs Armin Shokoohimand . Farnoosh Arfaee
. Ahmad Asghari . Ehsan Khaksar
Received: 27 November 2019 / Accepted: 22 May 2020 Ó Springer Nature B.V. 2020
Abstract Purpose The aim of this study was to evaluate the effects of 0.0015% preservative-free (PF) tafluprost alone and in combination with 0.5% timolol maleate or 0.5% betaxolol HCl on Schirmer tear test (STT), intraocular pressure (IOP), and pupil diameter (PD) in clinically normal dogs. Methods Twenty-one healthy adult castrated male cross-bred dogs were used in this study. Dogs were randomly divided into three groups. The first group received one drop of (PF) tafluprost (Taf), in a randomly selected eye. The second group received one drop of (PF) tafluprost plus one drop of timolol maleate (Taf-Tim), and the last group received one drop of (PF) tafluprost plus one drop of betaxolol HCl,
A. Shokoohimand F. Arfaee (&) A. Asghari Department of Clinical Science, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Hesarak, Tehran 1477893855, Islamic Republic of Iran e-mail: [email protected] A. Shokoohimand e-mail: [email protected] A. Asghari e-mail: [email protected] E. Khaksar Department of Clinical Science, Faculty of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar 3581631167, Islamic Republic of Iran e-mail: [email protected]
(Taf-Bet). In all groups, the fellow eyes were served as control and received one drop of saline as a placebo. IOP, STT, and PD measurements were performed at the baseline and every 30 min for the first 2 h, every 2 h for the next 10 h, and at 24 h and 36 h postinstillation (PI). Results In all groups, significant differences in IOP values were observed between treated and untreated eyes (Taf: p \ 0.001, Taf-Tim: p = 0.014, Taf-Bet: p = 0.008). The maximum reduction in mean IOP after unilateral administration of Taf, Taf-Tim, and Taf-Bet was 8.3 mmHg, 10.7 mmHg, and 13 mmHg, respectively. No significant differences in STT values were observed between treated and untreated eyes at any time points. In all groups, significant differences in PD values were observed between treated and untreated eyes in all time points except the baseline and 36 h post-drug instillation (p \ 0.001). Conclusions Tafluprost alone or in combination with timolol and betaxolol was able to reduce intraocular pressure. The greatest effect of the drugs occurred 6 and 8 h PI. The present study revealed that the combination of tafluprost/betaxolol is more potent in decreasing IOP than tafluprost alone or a combination of tafluprost/timolol in healthy dogs. Keywords Dogs Tafluprost Betaxolol Timolol Glaucoma Intraocular pressure
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Int Ophthalmol
Introduction Canine glaucoma (CG) is a sigh
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